Johns Hopkins School of Medicine

Irwin KE, Jasin P, Braunstein KE, Sinha I, Garret MA, Bowden KD, Chang K, Troncoso JC, Moghekar A, Oh ES, Raitcheva D, Bartlett D, Miller T, Berry JD, Traynor B, Ling JP and Wong PC: A fluid biomarker reveals loss of TDP-43 splicing repression in pre-symptomatic ALS-FTD. Nature Medicine 2024; doi.org/10.1038/s41591-023-02788-5.

Britson, K.A., Ling, J.P., Braunstein, K.E., Montagne, J., Kastenschmidt, J., Tsao, W., Russell, K.A., Reed, N., Wagner, K.R., Ostrow, L.W., Corse, A.M., Mammen, A.L., Villalta, A., Larman, H.B., Wong, P.C.*, and Lloyd, T.E.*: Loss of TDP-43 function and rimmed vacuoles persist after T cell depletion in a xenograft model of sporadic inclusion body myositis. Science Translational Medicine 14, eabi9196, January 19, 2022.
 
Donde A, Sun M, Ling JP, Braunstein KE, Pang B, Wen X, Cheng X, Chen L and Wong PC. Splicing repression is a major function of TDP‑43 in motor neurons. Acta Neuropathologica July 22, 2019 
(doi.org/10.1007/s00401-019-02042-8).
 

Jeong, Y.H., Ling, J.P., Lin, S.Z., Donde, A.N., Braunstein, K.E., Majounie, E., Traynor, B.J., LaClair, K.D., Lloyd, T.E. & Wong, P.C. Tdp-43 cryptic exons are highly variable between cell types. Molecular Neurodegeneration, 12(13), 2017. 

 
Sun M, Bell W, LaClair KD, Ling JP, Han H, Kageyama Y, Pletnikova O, Troncoso JC, *Wong PC and *Chen LLCryptic exon incorporation occurs in Alzheimer’s brain lacking TDP-43 inclusion but exhibiting nuclear clearance of TDP-43. Acta Neuropathologica 133:923-931, 2017.
 
Li, T., Braunstein K.E., Zhang, J., Lau, A., Sibener, L., Deeble, C., Wong, P.C. The neuritic plaque facilitates pathological conversion of tau in an Alzheimer's disease mouse model. Nature Communications, 7, 2016.

Ling, J.P., Pletnikova, O., Troncoso, J.C. & Wong, P.C. TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD. Science, 349:650-655, 2015