Mark Wu MD, PhD

Professor of Neurology




Lee, S.-S., Liu, Q., Cheng, A.H.R., Kim, D.W., Boudreau, D.M., Mehta, A., Keleş, M.F., Fejfer, R., Palmer, I., Park, K.H., Münzberg, H., Harris, T.D., Graves, A.R., Blackshaw, S., and Wu, M.N. (2025).  Sleep Need-Dependent Plasticity of a Thalamic Circuit Promotes Homeostatic Recovery Sleep.  Science 388, doi.org/10.1126/science.adm8203.  (Perspective in Science) 
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Keleş, M.F., Sapci, A.O.B., Brody, C., Palmer, I., Mehta, A., Ahmadi, S., Le, C., Tastan, Ö., Keleş, S., and Wu, M.N. (2025).  FlyVISTA, an Integrated Machine Learning Platform for Deep Phenotyping of Sleep in Drosophila.  Science Adv 11, doi.org/10.1126/sciadv.adq8131. 

Liu, Q., Xiong, J., Kim, D.W., Lee, S.-S., Bell, B.J., Alexandre, C., Blackshaw, S., Latremoliere, A., and Wu, M.N. (2024).  An amygdalar oscillator coordinates cellular and behavioral rhythms.  Neuron 112, 3750-3767. 

​Brown, M.P., Verma, S., Palmer, I., Zuniga, A.G., Mehta, A., Rosensweig, C., Keles, M.F., and Wu, M.N. (2024).  A subclass of evening cells promotes the switch from arousal to sleep at dusk.  Curr Biol 34, 2186-2199.  

​​Liu, Q.*, Bell, B.J.*, Kim, D.-W., Lee, S.-S., Keles, M.F., Liu, Q., Blum, I.D., Wang, A.A., Blank, E.J., Xiong, J., Bedont, J.L., Chang, A.J., Issa, H., Cohen, J.Y., Blackshaw, S., and Wu, M.N. (2023).  A Clock-Dependent Brake for Rhythmic Arousal in the Dorsomedial Hypothalamus.  Nat Commun 14, 6381.  

​Ho, M.C.W.*, Tabuchi, M.*, Xie, X., Brown, M., Luu, S., Wang, S., Kolodkin, A., Liu, S., and Wu, M.N. (2022).  Sleep Need-Dependent Changes in Functional Connectivity Facilitate Transmission of Homeostatic Sleep Drive.  Curr Biol 32, 4957-4966.  

​Blum, I.D.*, Keles, M.F.*, Baz, E.-S., Han, E., Park, K., Luu, S., Issa, H., Brown, M., Ho, M.C.W., Tabuchi, M., Liu, S.*, and Wu, M.N.* (2021).  Astroglial Calcium Signaling Encodes Sleep Need in Drosophila.  Curr Biol 31, 150-162.

​Tabuchi, M., Monaco, J.D., Duan, G., Bell, B., Liu, S., Liu, Q., Zhang, K., and Wu, M.N. (2018).  Clock-Generated Temporal Codes Determine Synaptic Plasticity to Control Sleep.  Cell 175, 1-15.

Liu, Q.*, Tabuchi, M.*, Liu, S., Kodama, L., Horiuchi, W., Daniels, J., Chiu, L., Baldoni, D., and Wu, M.N. (2017). Branch-Specific Plasticity of a Bifunctional Dopamine Circuit Encodes Protein Hunger.  Science 356, 534-539.

Liu, S.*, Liu, Q.*, Tabuchi, M., and Wu, M.N. (2016). Sleep Drive is Encoded by Neural Plastic Changes in a Dedicated Circuit.  Cell 165, 1347-1360.