Johns Hopkins School of Medicine

Liang X, Qiu X, Dionne G, Cunningham CL, Pucak ML, Peng G, Kim YH, Lauer A, Shapiro L, Müller U. CIB2 and CIB3 are auxiliary subunits of the mechanotransduction channel of hair cells. Neuron 2021; 109:2131-2149.

Alves Medeiros de Aroujo, J, Barao, S, Mateos-White, I, Espinosa, A, Costa, MR, Gil-Sanz, C, Müller, U. ZBTB20 is critical for the specification of a subset of callosal projection neurons and astrocytes in the mamalina cortex. Development 2021;148:dev196642.

Athey TL, Teneggi J, Vogelstein, JT, Tward, D, Müller, U, Miller, MI. Fitting splines to axonal arbors reveals relationship between branch order and geometry (2021).Frontiers Neuroinformatics 2021;15:704627.

Cunningham CL, Qiu X, Wu Z, Zhao B, Peng G, Kim YH, Lauer A, Müller U. (2020) TMIE defines pore and gating properties of the mechanotransduction channel of mammalian cochlear hair cells. Neuron 107, 126-143.

Dionne G, Qiu X, Rapp M, Liang X, Zhao B, Peng G, Katsamba PS, Ahlsen G, Rubinstein R, Potter CS, Carragher B, Honig B, Müller U,  and Shapiro L. (2018) Mechanotranduction by PCDH15 relies on a novel cis-dimeric architecture. Neuron 99, 480-492.

Cunningham CL, Wu Z, Jafari A, Zhao B, Schrode K, Harkins-Perry S, Lauer A, Müller U. (2017). The murine catecholamine methyltransferase mTOMT is essential for mechanotransduction by cochlear hair cells. Elife. 6. pii: e24318.

Sun S, Babola T, Pregernig G, So KS, Nguyen M, Su SM, Palermo AT, Bergles DE, Burns JC, and Müller U. (2018). Hair cell mechanotransduction regulates spontaneous activity and spiral ganglion subtype specification in the auditory system. Cell 174, 1747-1263.

Wu Z, Grillet N, Zhao B, Cunningham C, Harkins-Perry S, Coste B, Ranade S, Zebarjadi N, Beurg M, Fettiplace R, Patapoutian A, and Müller U. (2017). Mechanosensory hair cells express two molecularly distinct mechanotransduction channels. Nat Neurosci. 20, 24-33.

Zhao B, Wu Z,  and Müller U. (2016). Murine Fam65b forms ring-like structures at the base of stereocilia critical for mechanosensory hair cell function. Elife, 5.

Martinez-Garay I, Gil-Sanz C, Franco SJ, Espinosa A, Molnár Z, and Müller U. (2016). Cadherin 2/4 signaling via PTP1B and catenins is crucial for nucleokinesis during radial neuronal migration in the neodortex. Development143, 2121-2134.

Müller, U., and Gillespie, P. (2015). New treatment options for hearing loss. Nat. Rev. Drug Discovery 14, 346-365.

Gil-Sanz, C. and Müller, U. (2015). A new chapter in the life of Cajal's short-axon neurons: separation of interneuron siblings after birth. Neuron 87, 909-911.

Xiong, W., Wagner, T., Yan, L., Grillet, N., and Müller, U. (2014). Injectoporation: An efficient gene delivery method for the annotation of gene function in mechanosensory hair cells. Nature Protocols 9, 2438-2494.

Gil-Sanz, C., Espinosa A., Fregoso S.P., Bluske, K.K., Cunningham, C.L., Martinez-Garay, I., Zeng, H., Franco,S.J., and Müller, U. (2014). Linege tracing using Cux2-Cre and Cux2-CreERT2 mice. Neuron 86,1091-1099.

Zhao, B., Wu, Z., Grillet, N., Yan, L., Xiong. W., Harkins-Perry, S., and Müller, U. (2014). TMIE is an essential component of the mechanotransduction machinery of cochlear hair cells. Neuron 84, 954-967.

Gil-Sanz, C., Franco, S.J., Martinez-Garay, I., Espinosa, A., Harkins-Perry, S., and Müller, U. (2013). Cajal-Retzius cells instruct neuronal migration by coincidence signaling between secreted and contact-dependent guidance cues. Neuron 79, 461-477.

Xiong, W., Grillet, N., Elledge, H., Wagner, T.F.J., Zhao, B, Johnson, K.R., Kazmierczak, P., and Müller, U. (2012). TMHS is an integral component of the mechanotransduction machienry of cochlear hair cells. Cell 151, 1283-1295.

Franco S.J., and Müller, U. (2012). Shaping our minds: stem and progenitor cell diversity in the mammalian neocortex. Neuron 77, 19-34.

Franco, S.J., Gil-Sanz, C. Martinez-Garay, I., Espinosa, A., Harkins-Perry, S.R., Ramos, C., and Müller, U. (2012). Fate-restricted neural progenitors in the mammalian cerebral cortex. Science 337, 746-749.

Reelin signaling regulates cadherin function through Dab1/Rap1 to regulate migration and lamination in the cerebral cortex (2011). Franco, S.J., Martinez-Garay, I., Gil-Sanz, C., Harkins-Perry, S.R., and Müller U., Neuron 69, 482-497.

Gillespie, P., and Müller, U. (2009). Mechanotransduction by hair cells: models, molecules, and mechanisms. Cell 139, 33-44.

Grillet, N., Kazmierczak, P., Xiong, W., Schwander, M., Reynolds, A., Sakaguchi, H., Tokita, J., Kachar, B., and Müller, U. (2009). The mechanotransduction machinery of hair cells. Sci. Signal. 2, pt5.

Grillet, N., Xiong, W., Reynolds, A., Kazmierczak, P., Sato, T., Lillo, C., Dumont, R.A., Hintermann, E., Sczaniecka, A., Schwander, M., Williams, D., Kachar, B., Gillespie, P.G., and Müller, U. (2009). Harmonin mutations cause mechanotransduction defects in cochlear hair cells. Neuron 62, 345-387.

Kazmierczak, P.$, Sakaguchi, H., Tokita, J., Wilson-Kubalek, E.M., Milligan, R.A., Müller, U.*, and Kachar, B.* (2007). Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells. Nature 449, 87-91. $ First author from Müller laboratory, * co-corresponding authors

Schwander, M., Sczaniecka, A., Grillet, N., Bailey, J.S., Avenarius, M., Najmabadi, H., Steffy, B.M., Federe, G.C., Lagler, E.A., Banan, R., Hice, R., Grabowski, L., Keithley, E.M., Ryan, A.F., Housley, G.D., Wiltshire, T., Smith, R.J.H., Tarantino, L.M., and Müller, U. (2007). A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function. J. Neurosci. 27, 2163-2175.

Siemens, J., Lillo, C., Dumont, R.A., Williams, D., Gillespie, P.G., and Müller. U. (2004). CDH23 is a component of the tip link in hair cell stereocilia. Nature 428, 950-955.

Graus-Porta, D., Blaess, S., Senften, M., Littlewood-Evans, A., Damsky, C., Huang, Z., Orban, P., Klein, R., Schittney, J.C., and Müller, U. (2001). β1 class integrins regulate the development of laminae and folia in the cerebral and cerebellar cortex. Neuron 31, 367-379.