Johns Hopkins School of Medicine

The Solomon H. Snyder Department of Neuroscience

Alban Latremoliere PhD

Assistant Professor of Neurosurgery

• Alexandre C, Miracca G, Holanda VD, Sharma A, Kourbanova K, Ferreira A, Bicca MA, Zeng X, Nassar VA, Lee S, Kaur S, Sarma SV, Sacré P, Scammell TE, Woolf CJ, Latremoliere A. Nociceptor spontaneous activity is responsible for fragmenting non-rapid eye movement sleep in mouse models of neuropathic pain. Sci Transl Med. 2024 Apr 17;16(743):eadg3036. doi: 10.1126/scitranslmed.adg3036. Epub 2024 Apr 17. PMID: 38630850.
• Liu Q, Xiong J, Kim DW, Lee SS, Bell BJ, Alexandre C, Blackshaw S, Latremoliere A, Wu MN. An amygdalar oscillator coordinates cellular and behavioral rhythms. Neuron. 2024 Sep 18:S0896-6273(24)00609-3.doi: 10.1016/j.neuron.2024.08.013.
• Jeon SM, Pradeep A, Chang D, McDonough L, Chen Y, Latremoliere A, Crawford LK, Caterina MJ. Skin Reinnervation by Collateral Sprouting Following Spared Nerve Injury in Mice. J Neurosci. 2024 Apr 10;44(15):e1494232024. doi: 10.1523/JNEUROSCI.1494-23.2024. PMID: 38471780; PMCID: PMC11007315.
• Cronin SJF, Andrews NA, Latremoliere A. Peripheralized sepiapterin reductase inhibition as a safe analgesic therapy. Front Pharmacol. 2023 May 12;14:1173599. doi: 10.3389/fphar.2023.1173599. PMID: 37251335; PMCID: PMC10213231.
• Sprague JM, Yekkirala AS, Singh B, Tochitsky I, Stephens M, Viramontes O, Ivanis J, Biscola NP, Havton LA, Woolf CJ, Latremoliere A. Bortezomib-induced neuropathy is in part mediated by the sensitization of TRPV1 channels. Commun Biol. 2023 Dec 5;6(1):1228. doi: 10.1038/s42003-023-05624-1. PMID: 38052846; PMCID: PMC10698173.
• Kourbanova K, Alexandre C and Latremoliere A (2022) Effect of sleep loss on pain—New conceptual and mechanistic avenues. Front. Neurosci. 16:1009902. doi: 10.3389/fnins.2022.100990
• Jha, M. K., Passero, J. V., Rawat, A., Ament, X. H., Yang, F., Vidensky, S., Collins, S. L., Horton, M. R., Hoke, A., Rutter, G. A., Latremoliere, A., Rothstein, J. D., & Morrison, B. M. (2021). Macrophage monocarboxylate transporter 1 promotes peripheral nerve regeneration after injury in mice. Journal of Clinical Investigation, 131(21). PMID: 34491913.
• Fujita, M., Scheffer, D. D. L., Turnes, B. L., Cronin, S. J. F., Latrémolière, A., Costigan, M., Woolf, C. J., Latini, A., & Andrews, N. A. (2019). Sepiapterin Reductase Inhibition Leading to Selective Reduction of Inflammatory Joint Pain in Mice and Increased Urinary Sepiapterin Levels in Humans and Mice. Arthritis & Rheumatology, 72(1), 57–66. PMID: 31350812.
• Cronin, S.J.F., Seehus, C., Weidinger, A. et al. The metabolite BH4 controls T cell proliferation in autoimmunity and cancer. Nature 563, 564–568 (2018). PMID: 30405245.
• Inquimbert, P., Moll, M., Latremoliere, A., Tong, C. K., Whang, J., Sheehan, G. F., Smith, B. M., Korb, E., Athié, M. C., Babaniyi, O., Ghasemlou, N., Yanagawa, Y., Allis, C. D., Hof, P. R., & Scholz, J. (2018). NMDA Receptor Activation Underlies the Loss of Spinal Dorsal Horn Neurons and the Transition to Persistent Pain after Peripheral Nerve Injury. Cell Reports, 23(9), 2678–2689. PMID: 29847798.
• Latremoliere, A., Costigan, M. Combining Human and Rodent Genetics to Identify New Analgesics. Neurosci. Bull. 34, 143–155 (2018). PMID: 28667479.
• Liu Y*, Latremoliere A*, Li X*, Zhang Z*, Chen M, Wang X, Fang C, Zhu J, Alexandre C, Gao Z, Chen B, Ding X, Zhou JY, Zhang Y, Chen C, Wang KH, Woolf CJ, He Z. (2018) Touch and tactile neuropathic pain sensitivity are set by corticospinal projections. Nature. 2018 PMID: 30209395. 
• Latremoliere A*, Cheng L*, DeLisle M, Wu C, Chew S, Hutchinson EB, Sheridan A, Alexandre C, Latremoliere F, Sheu SH, Golidy S, Omura T, Huebner EA, Fan Y, Whitman MC, Nguyen E, Hermawan C, Pierpaoli C, Tischfield MA, Woolf CJ, Engle EC. (2018) Neuronal-Specific TUBB3 Is Not Required for Normal Neuronal Function but Is Essential for Timely Axon Regeneration. Cell Rep. PMID: 30110642. 
• Browne LE, Latremoliere A*, Lehnert BP, Grantham A, Ward C, Alexandre C, Costigan M, Michoud F, Roberson DP, Ginty DD, Woolf CJ. (2017) Time-Resolved Fast Mammalian Behavior Reveals the Complexity of Protective Pain Responses. Cell Rep. PMID: 28683326
• Alexandre C*, Latremoliere A*, Ferreira A, Miracca G, Yamamoto M, Scammell TE, Woolf CJ. (2017) Decreased alertness due to sleep loss increases pain sensitivity in mice. Nat Med. PMID: 28481358.
• Andrews NA*, Latremoliere A*, Basbaum AI, Mogil JS, Porreca F, Rice AS, Woolf CJ, Currie GL, Dworkin RH, Eisenach JC, Evans S, Gewandter JS, Gover TD, Handwerker H, Huang W, Iyengar S, Jensen MP, Kennedy JD, Lee N, Levine J, Lidster K, Machin I, McDermott MP, McMahon SB, Price TJ, Ross SE, Scherrer G, Seal RP, Sena ES, Silva E, Stone L, Svensson CI, Turk DC, Whiteside G. (2016) Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations. Pain. PMID: 26683237. 
• Kahle, K. T., Schmouth, J. F., Lavastre, V., Latremoliere, A., Zhang, J., Andrews, N., Omura, T., Laganière, J., Rochefort, D., Hince, P., Castonguay, G., Gaudet, R., Mapplebeck, J. C., Sotocinal, S. G., Duan, J., Ward, C., Khanna, A. R., Mogil, J. S., Dion, P. A., Woolf, C. J., … Rouleau, G. A. (2016). Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition. Science signaling, 9(421), ra32. PMID: 27025876.
• Belin, S., Nawabi, H., Wang, C., Tang, S., Latremoliere, A., Warren, P., Schorle, H., Uncu, C., Woolf, C. J., He, Z., & Steen, J. A. (2015). Injury-Induced Decline of Intrinsic Regenerative Ability Revealed by Quantitative Proteomics. Neuron, 86(4), 1000–1014. PMID: 25937169.
• Latremoliere A, Latini A, Andrews N, Cronin SJ, Fujita M, Gorska K, Hovius R, Romero C, Chuaiphichai S, Painter M, Miracca G, Babaniyi O, Remor AP, Duong K, Riva P, Barrett LB, Ferreirós N, Naylor A, Penninger JM, Tegeder I, Zhong J, Blagg J, Channon KM, Johnsson K, Costigan M, Woolf CJ. (2015) Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway. Neuron. PMID: 26087165.
• Nawabi, H., Belin, S., Cartoni, R., Williams, P., Wang, C., Latremolière, A., Wang, X., Zhu, J., Taub, D., Fu, X., Yu, B., Gu, X., Woolf, C., Liu, J., Gabel, C., Steen, J., & He, Z. (2015). Doublecortin-Like Kinases Promote Neuronal Survival and Induce Growth Cone Reformation via Distinct Mechanisms. Neuron, 88(4), 704–719. PMID: 26526391.
• Omura, T., Omura, K., Tedeschi, A., Riva, P., Painter, M., Rojas, L., Martin, J., Lisi, V., Huebner, E., Latremoliere, A., Yin, Y., Barrett, L. B., Singh, B., Lee, S., Crisman, T., Gao, F., Li, S., Kapur, K., Geschwind, D., . . . Woolf, C. (2015). Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS. Neuron, 86(5), 1215–1227. PMID: 26004914.
• Vicuña L, Strochlic DE, Latremoliere A, Bali KK, Simonetti M, Husainie D, Prokosch S, Riva P, Griffin RS, Njoo C, Gehrig S, Mall MA, Arnold B, Devor M, Woolf CJ, Liberles SD, Costigan M, Kuner R. (2015) The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase. Nat Med. PMID: 25915831