Mark P. Mattson PhD
Adjunct Professor of Neuroscience
Adjunct Professor of Neuroscience
Selected publications
Kapogiannis D, Manolopoulos A, Mullins R, Avgerinos K, Delgado-Peraza F, Mustapic M, Nogueras-Ortiz C, Yao PJ, Pucha KA, Brooks J, Chen Q, Haas SS, Ge R, Hartnell LM, Cookson MR, Egan JM, Frangou S, Mattson MP. Brain responses to intermittent fasting and the healthy living diet in older adults. Cell Metab. 2024; 36:1668-1678.
Mattson MP, Leak RK. The hormesis principle of neuroplasticity and neuroprotection. Cell Metab. 2024; 36:315-337.
Mattson MP (2023) “Sculptor and Destroyer: Tales of Glutamate, the Brain’s Most Important Neurotransmitter. MIT Press, Cambridge MA. 298 pp.
Mattson MP (2022)“The Intermittent Fasting Revolution: The Science of Optimizing Health and Enhancing Performance” MIT Press, Cambridge MA. 234 pp.
Liu Y, Cheng A, Li Y, Yang Y, Kishimoto Y, Zhang S, Wang Y, Wan R, Raefsky SM, Lu D, Saito T, Saido T, Zhu J, Wu L, Mattson MP. SIRT3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in APP mutant mice. Nature Commun. 2019; 10(1):1886.
Zhang P, Kishimoto Y, Grammatikakis I, Gottimukkala K, Cutler RG, Zhang S, Abdelmohsen K, Bohr VA, Sen JM, Gorospe M, Mattson MP. (2019) Senolytic therapy ameliorates amyloid-associated cellular senescence, inflammation and cognitive deficits in an Alzheimer’s disease model. Nat. Neurosci. 2019; 22:719-728.
de Cabo R, Mattson MP. Effects of Intermittent Fasting on Health, Aging, and Disease. N Engl J Med. 2019; 381:2541-2551.
Fang EF, Hou Y, Palikaras K, Adriaanse BA, Kerr JS, Yang B, Lautrup S, Hasan-Olive MM, Caponio D, Dan X, Rocktäschel P, Croteau DL, Akbari M, Greig NH, Fladby T, Nilsen H, Cader MZ, Mattson MP, Tavernarakis N, Bohr VA. Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease. Nat Neurosci. 2019; 22:401-412.
Mattson MP, Moehl K, Ghena N, Schmaedick M, Cheng A. Intermittent metabolic switching, neuroplasticity and brain health. Nat Rev Neurosci. 2018; 19:63-80.
Mattson MP, Arumugam TV. Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States.Cell Metab. 2018; 27:1176-1199.
Camandola S, Mattson MP. Brain metabolism in health, aging, and neurodegeneration. EMBO J. 2017; 36:1474-1492.
Cheng A, Yang Y, Zhou Y, Maharana C, Lu D, Peng W, Liu Y, Wan R, Marosi K, Misiak M, Bohr VA, Mattson MP. Mitochondrial SIRT3 Mediates Adaptive Responses of Neurons to Exercise and Metabolic and Excitatory Challenges. Cell Metab. 2016; 23:128-142.