Johns Hopkins School of Medicine

Engelender S, Kaminsky Z, Guo X, Sharp AH, Amaravia RK, Kleiderlein JJ, Margolis RL, Troncoso JC, Lanahan AA, Worley PF, Dawson VL, Dawson TM, Ross CA. Synphilin-1 Associated with alpha-synuclein and Promotes the Formation of Cytosolic Inclusions. Nature Genetics 22:110-114, 1999. [PDF]

Schilling G, Wood JD, Duan K, Slunt HH, Gonzales V, Yamada M, Cooper JK, Margolis RL, Jenkins NA, Copeland NG, Takahashi H, Tsuji S, Price DL, Borchelt DR, Ross CA. Related Articles Nuclear accumulation of truncated atrophin-1 fragments in a transgenic mouse model of DRPLA. Neuron. 1999 Sep;24(1):275-86. [PDF]

Wakabayashi K, Engelender S, Yoshimoto M, Tsuji S, Ross CA, Takahashi H. Synphilin-1 is present in Lewy bodies in Parkinson's disease. Ann Neurol. 2000 Apr;47(4):521-3. [PDF]

Wood JD, Nucifora FC Jr, Duan K, Zhang C, Wang J, Kim Y, Schilling G, Sacchi N, Liu JM, Ross CA. Atrophin-1, the dentato-rubral and pallido-luysian atrophy gene product, interacts with ETO/MTG8 in the nuclear matrix and represses transcription. J Cell Biol. 2000 Sep 4;150(5):939-48. [PDF]

Peters MF, Ross CA. Isolation of a 40-kDa Huntingtin-associated protein. J Biol Chem. 2001 Feb 2;276(5):3188-94.[PDF]

Nucifora FC Jr, Sasaki M, Peters MF, Huang H, Cooper JK, Yamada M, Takahashi H, Tsuji S, Troncoso J, Dawson VL, Dawson TM, Ross CA. Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity. Science. 2001 Mar 23;291(5512):2423-8. [PDF]

Margolis RL, O'Hearn E, Rosenblatt A, Willour V, Holmes SE, Franz ML, Callahan C, Hwang HS, Troncoso JC, Ross CA. A disorder similar to Huntington's disease is associated with a novel CAG repeat expansion. Ann Neurol. 2001 Sep;50(3):373-80.

Chung KK, Zhang Y, Lim KL, Tanaka Y, Huang H, Gao J, Ross CA, Dawson VL, Dawson TM. Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease. Nat Med. 2001 Oct;7(10):1144-50. [PDF]

Nucifora  FC Jr, Sasaki M, Peters MF, Huang H, Cooper JK, Yamada M, Takahashi H, Tsuji S, Troncoso J, Dawson VL, Dawson TM, Ross CA.   Interference by huntingtin and atrophin-1 with CBP-mediated transcription leading to cellular toxicity. Science. 2001 Mar 23;291(5512):2423-8.  [PDF]

de Almeida LP, Ross CA, Zala D, Aebischer P, Deglon N. Lentiviral-mediated delivery of mutant huntingtin in the striatum of rats induces a selective neuropathology modulated by polyglutamine repeat size, huntingtin expression levels, and protein length. J Neurosci. 2002 May 1;22(9):3473-83. [PDF]

Ross CA. Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington's disease and related disorders. Neuron. 2002 Aug 29;35(5):819-22. Review. [PDF]

Ross CA.  Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington's disease and related disorders. Neuron. 2002 Aug 29;35(5):819-22.  [PDF] 
 

Ozeki Y, Tomoda T, Kleiderlein J, Kamiya A, Bord L, Fujii K, Okawa M, Yamada N, Hatten ME, Snyder SH, Ross CA, Sawa A.   Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth. Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):289-94.  [PDF]

Ross CA, Poirier MA. Protein aggregation and neurodegenerative disease. Nat Med. 2004 Jul;10 Suppl:S10-7. [PDF]

Ross CA. Huntington's disease: new paths to pathogenesis. Cell. 2004 Jul 9;118(1):4-7. [PDF]

Ross CA, Poirier MA.   Protein aggregation and neurodegenerative disease. Nature Medicine 2004 Jul;10 Suppl:S10-7. [PDF]

Smith WW, Pei Z, Jiang H, Moore DJ, Liang Y, West AB, Dawson VL, Dawson TM, Ross CA.   Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration. Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18676-81.  [PDF]
 
Ross CA, Poirier MA.   What is the role of protein aggregation in neurodegeneration?  Nat Rev Mol Cell Biol. 2005 Nov;6(11):891-8.  [PDF]
 
Wang W, Duan W, Igarashi S, Morita H, Nakamura M, Ross CA.  Compounds blocking mutant huntingtin toxicity identified using a Huntington's disease neuronal cell model. Neurobiol Dis. 2005 Nov;20(2):500-8. 

Ross CA, Margolis RL, Reading SA, Pletnikov M, Coyle JT.   Neurobiology of schizophrenia. Neuron. 2006 Oct 5;52(1):139-53.
 
Jiang H, Poirier MA, Liang Y, Pei Z, Weiskittel CE, Smith WW, DeFranco DB, Ross CA.   Depletion of CBP is directly linked with cellular toxicity caused by mutant huntingtin. Neurobiol Dis. 2006 Sep;23(3):543-51.  [PDF]

Smith WW, Pei Z, Jiang H, Dawson VL, Dawson TM, Ross CA.   Kinase activity of mutant LRRK2 mediates neuronal toxicity. Nature Neurosci. 2006 Oct;9(10):1231-3. [PDF]