Jiou Wang MD, PhD

Professor of Biochemistry and Molecular Biology




Wang T, Liu H, Itoh K, Zhang L, Sesaki H, Hartung T, Wang J. (2021) C9orf72 Regulates Energy Homeostasis by Stabilizing Mitochondrial Complex I Assembly. Cell Metabolism doi: 10.1016/j.cmet.2021.01.005

Zhang T, Periz, Lu Y, Wang J. (2020) USP7 regulates ALS-associated proteotoxicity and quality control through the NEDD4L-SMAD pathway. PNAS doi: 10.1073/pnas.2014349117.

Simko E, Liu H, Zhang T, Velasquez A, Teli S, Haeusler AR, Wang J. (2020) G-quadruplexes offer a conserved structural motif for NONO recruitment to NEAT1 achitectual IncRNA. Nucleic Acids Res. 48:7421-7438.

Ji Y, Ugolino J, Zhang T, Lu J, Kim D, Wang J. (2020) C9orf72/ALFA-1 Controls TFEB/HLH-30-dependent Metabolism Through Dynamic Regulation of Rag GTPases. PLoS Genetics 16(4):e1008738.

Lu J, Periz G, Lu YN, Tang Q, Liu Y, Zhang T, Shah Y, Thombre R, Aljumaah R, Li W, Mojsilovic-Petrovic J, Ji Y, Johnson K, Kalb R, Wang J. (2019) L3MBTL1 regulates ALS/FTD-associated proteotoxicity and quality control. Nature Neuroscience. doi: 10.1038/s41593-019-0384-5.

Alexander E, Niaki A, Zhang T, Sarkar J, Liu Y, Nirujogi R, Pandey A, Myong S, Wang J. (2018) Ubiquilin 2 Modulates ALS/FTD-linked FUS-RNA Complex Dynamics and Stress Granule Formation. Proc. Natl. Acad. Sci. USA doi.org/10.1073/pnas.18119977115.

Liu Y, Wang T, Ji Y, Johnson K, Liu H, Johnson K, Bailey S, Suk Y, Lu Y, Liu M, Wang J. (2018) A C9orf72-CARM1 Axis Regulates Lipid Metabolism Under Glucose Starvation-induced Nutrient Stress. Genes & Development 32:1-18.

Zhang T, Wu Y, Mullane P, Ji Y, Liu H, He L, Arora A, Hwang H, Alessi A, Niaki A,Periz G, Guo L, Wang H, Elkayam E, Joshua-Tor L, Myong S, Kim J, Shorter J, Ong S, Leung A, Wang J. (2018) FUS Regulates Activity of MicroRNA-mediated Gene Silencing. Molecular Cell 69:787-801.

Hwang H-Y, Wang J (2017) Effect of mutation mechanisms on variant composition and distribution in Caenorhabditis elegans. PLoS Comput Biol 13(1): e1005369. doi:10.1371/journal.pcbi.1005369.

Ugolino J, Ji YJ, Conchina K, Chu J, Nirujogi RS, Pandey A, Brady N, Hamacher-Brady A, Wang J. (2016) Loss of C9orf72 Enhances Autophagic Activity via Deregulated mTOR and TFEB Signaling. PLoS Genet 12(11): e1006443.

Periz G, Lu J, Kankle M, Jablonski A, Kalb R, McCampbell A, Wang J. (2015) Regulation of protein quality control by UBE4B and LSD1 through p53-mediated transcription. PLoS Biology 13(4):e1002114.

Zhang T, Baldie G, Periz G, Wang J. (2014) RNA-processing protein TDP-43 regulates FOXO-dependent protein quality control in stress response. PLoS Genetics 10(10): e1004693.

Haeusler AR, Donnelly C, Periz G, Simko E, Shaw P, Kim M, Maragakis N, Troncoso J, Pandey A, Sattler R, Rothstein J, and Wang J. (2014) C9orf72 Nucleotide Repeat Structures Initiate Molecular Cascade of Disease. Nature 507:195-200.

Zhang T, Hwang H.Y., Hao H., Talbot C., Jr., and Wang J. (2012) Caenorhabditis elegans RNA-processing Protein TDP-1 Regulates Protein Homeostasis and Lifespan. J Biol Chem. 287, 8371-8382 (Paper of the Week)

Zhang T, Mullane PC, Periz G, Wang J. (2011) TDP-43 Neurotoxicity and Protein Aggregation Modulated by Heat Shock Factor and Insulin/IGF-1 Signaling. Human Molecular Genetics 20, 1952-1965. [PDF]