Seth Blackshaw PhD

Professor of Neuroscience




Stein-O’Brien GL, Clark BS, Sherman T, Hu Q, Sealfon R, Wolf A, Zibetti C, Liu S, Qian J, Colantuoni C, Beer M, Blackshaw S, Goff LA, and Fertig EJ. Decomposing cell identity for transfer learning across platforms, tissues and species. Cell Systems, in press.

Clark BS, Stein-O’Brien GL, Shiau F, Cannon GH, Davis E, Sherman T, Rajaii F, James-
Esposito RE, Gronostajski RM, Fertig EJ, Goff LA, and Blackshaw S. Comprehensive analysis of retinal development at single cell resolution identifies NFI factors as essential for mitotic exit and specification of late-born cells. Neuron, in press.

Zibetti C, Liu S, Wan J, Qian J, and Blackshaw S. Lhx2 regulates temporal changes in chromatin accessibility and transcription factor binding in retinal progenitor cells. Comm Biology 2019, 2:142.

Yoo S, Cha D, Kim DW, Hoang T, and Blackshaw S. Tanycyte-independent regulation
of leptin signaling. Frontiers in Neuroscience 2019,
https://doi.org/10.3389/fnins.2019.00240

Ling JP, Wilks C, Charles R, Ghosh D, Jiang L, Santiago CP, Pang B, Venkataraman A, Clark BS, Nellore A, Langmead B, and Blackshaw S. ASCOT identifies key regulators of neuronal subtype-specific RNA splicing. bioRxiv 2018, 501882.

Newman EA, Wan J, Wang J, Jiang, Qian J, and Blackshaw S.Foxd1 is required for terminal differentiation of anterior hypothalamic neuronal subtypes. Dev Biol 2018 439:102-111.

Newman EA, Wu D, Makoto MM, Zhang J, and Blackshaw S. Canonical Wnt signaling
regulates patterning, differentiation and nucleogenesis in mouse hypothalamus and prethalamus. Dev Biol 2018, 442:236-248.

Wang J, Zibetti C, Shang P, Sripathi SR, Zhang P, Cano M, Ji H, Merbs SL, Zack DJ, Handa J, Sinha D, Blackshaw S* and Qian J*. A widespread decrease in chromatin accessibility in age-related macular degeneration. Nat Comm 2018 9:1364 (* indicates co-corresponding author).

de Melo J, Venkataraman A, Clark BS, Shiau F, Zibetti C, and Blackshaw S. Ldb1 and Rnf12-dependent regulation of Lhx2 controls the relative balance between neurogenesis and gliogenesis in retina. Development 2018 145. pii: dev159970. doi: 10.1242/dev.159970

Venkataraman A, Yang K, Irizarry J, Mackiewicz M, Mita P, Kuang K Xue L, Ghosh D, Liu S, Ramos P, Hu S, Bayron D, Keegan S, Saul R, Colantonio S, Zhang H, Behn FP, Song G, Albino E, Asencio L, Ramos L, Lugo L, Morell G, Rivera J, Ruiz K, Almodovar R, Nazario L, Murphy K, Vargas I, Rivera-Pacheco ZA, Rosa C, Vargas M, McDade J, Clark BS, Yoo S, Seva G. Khambadkone5, de Melo J, Stevanovic M, Jiang L, Li Y, Yap WY, Jones B, Tandon A, Campbell E, Anderson S, Myers RM, Boeke JD, Fenyo D, Whiteley G, Bader JS, Pino I, Eichinger DJ, Zhu H, and Blackshaw S. A toolbox of immunoprecipitation-grade monoclonal antibodies against human transcription factors. Nat Methods 2018 doi: 10.1038/nmeth.4632.

Liu K, Kim J, Kim DW, Zhang S, Denaxa M, Bao H, Lim SA, Kim E, Liu C, Wickersham IR, Pachinis V, Hattar S, Song J, Brown SR, and Blackshaw S. Lhx6-positive GABAergic neurons of the zona incerta promote sleep. Nature 2017 548:582-587.

Bedont JL, LeGates TA, Buhr E, Bathini A, Ling J, Wong P, van Gelder R, Mongrain V, Hattar S, and Blackshaw S, An Lhx1-Regulated Transcriptional Network Controls Sleep-Wake Coupling and Thermal Resistance of the Central Circadian Clockworks. Curr Biol 2017 27:128-136.

De Melo J, Zibetti C, Clark BS, Hwang W, Miranda-Angulo AL, Qian J, Blackshaw S. Lhx2 Is an Essential Factor for Retinal Gliogenesis and Notch Signaling. J Neurosci 2016 36:2391-405.

De Melo J, Clark BS, and Blackshaw S. Multiple intrinsic factors act in concert with Lhx2 to direct retinal gliogenesis. Sci Reports 2016 6:32757.

Thein T, de Melo J, Zibetti C, Clark BS, Juarez F, and Blackshaw S. Control of lens development by Lhx2-regulated neuroretinal FGFs. Development 2016 143: 3994-4002

Salvatierra J, Lee DA, Zibetti C, Duran-Moreno M, Yoo S, Newman EA, Wang H, Bedont JL, de Melo J, Miranda-Angulo AL, Gil-Perotin S, Garcia-Verdugo JM, and Blackshaw S. The LIM homeodomain factor Lhx2 is required for hypothalamic tanycyte specification and differentiation. J Neurosci 2014 34:16809-20.

Bedont JL, LeGates TA, Slat EA , Byerly MS, Wang H, Hu J, Rupp AC, Qian J, Wong GW, Herzog ED, Hattar S, and Blackshaw S. Lhx1 controls terminal differentiation and circadian function of the suprachiasmatic nucleus. Cell Reports 2014 7:609-22.

Jeong JS, Jiang L, Albino E, Marrero J, Rho HS, Hu S, Woodard C, Vera C, Bayron-Poueymirou D, Rivera-Pacheco ZA, Ramos L, Torres-Castro C, Bonaventura J, Boeke JD, Pino I, Eichinger DJ, Zhu H and Blackshaw S. A human proteome microarray-based pipeline for efficient production of monospecific monoclonal antibodies. Mol Cell Proteomics 2012 11:O111.016253.

De Melo J, Miki K, Rattner A, Smallwood P, Hirokawa K, Monuki ES, Campochario P, and Blackshaw S. Injury-independent induction of reactive gliosis in retinal Muller glia by loss of function of the LIM homeodomain transcription factor Lhx2. Proc Natl Acad Sci USA 2012 109:4657-62.

Lee DA, Pak T, Bedont JL, Wang H, Miranda-Angulo A, Takiar V, Charubhumi V, Balordi F, Takebayashi H, Fishell G, Ford E and Blackshaw S. Tanycytes of the median eminence form a dietary-responsive neurogenic niche. Nat Neurosci 2012 15:700-2.

Shimogori T, Lee D A, Miranda-Angulo A, Yang Y, Yoshida A, Jiang L, Kataoka A, Wang H, Mashiko H, Avetisyan M A, Qi L, Qian J, and Blackshaw S. A genomic atlas of mouse hypothalamic development. Nat Neurosci 2010 13:767-75.

Onishi A, Peng GH, Chen S, Blackshaw S. Pias3-dependent SUMOylation controls mammalian cone photoreceptor differentiation. Nat Neurosci 2010 13:1059-65