Paul Worley MD

Professor of Neuroscience




For a more complete list of publications, click here.

1.         Soldan A, Moghekar A, Walker KA, Pettigrew C, Hou X, Lu H, Miller MI, Alfini A, Albert M, Xu D, Xiao MF, Worley P, Team BR. Resting-State Functional Connectivity Is Associated With Cerebrospinal Fluid Levels of the Synaptic Protein NPTX2 in Non-demented Older Adults. Front Aging Neurosci. 2019;11:132. Epub 2019/06/25. doi: 10.3389/fnagi.2019.00132. PubMed PMID: 31231205; PMCID: PMC6568192.

2.         Zhang W, Chuang YA, Na Y, Ye Z, Yang L, Lin R, Zhou J, Wu J, Qiu J, Savonenko A, Leahy DJ, Huganir R, Linden DJ, Worley PF. Arc Oligomerization Is Regulated by CaMKII Phosphorylation of the GAG Domain: An Essential Mechanism for Plasticity and Memory Formation. Mol Cell. 2019;75(1):13-25 e5. Epub 2019/06/04. doi: 10.1016/j.molcel.2019.05.004. PubMed PMID: 31151856; PMCID: PMC6625847.

3.         Piard J, Hu JH, Campeau PM, Rzonca S, Van Esch H, Vincent E, Han M, Rossignol E, Castaneda J, Chelly J, Skinner C, Kalscheuer VM, Wang R, Lemyre E, Kosinska J, Stawinski P, Bal J, Hoffman DA, Schwartz CE, Van Maldergem L, Wang T, Worley PF. FRMPD4 mutations cause X-linked intellectual disability and disrupt dendritic spine morphogenesis. Human molecular genetics. 2018;27(4):589-600. Epub 2017/12/22. doi: 10.1093/hmg/ddx426. PubMed PMID: 29267967; PMCID: PMC5886117.

4.         Chang AD, Vaidya PV, Retzbach EP, Chung SJ, Kim U, Baselice K, Maynard K, Stepanian A, Staley M, Xiao L, Blouin A, Han S, Lee J, Worley PF, Tamashiro KL, Hempstead BL, Martinowich K, Ann Wilson M, Baraban JM, Reti IM. Narp Mediates Antidepressant-Like Effects of Electroconvulsive Seizures. Neuropsychopharmacology. 2018;43(5):1088-98. Epub 2017/10/21. doi: 10.1038/npp.2017.252. PubMed PMID: 29052614; PMCID: PMC5854807.

5.         Xiao MF, Xu D, Craig MT, Pelkey KA, Chien CC, Shi Y, Zhang J, Resnick S, Pletnikova O, Salmon D, Brewer J, Edland S, Wegiel J, Tycko B, Savonenko A, Reeves RH, Troncoso JC, McBain CJ, Galasko D, Worley PF. NPTX2 and cognitive dysfunction in Alzheimer's Disease. Elife. 2017;6. Epub 2017/04/26. doi: 10.7554/eLife.23798. PubMed PMID: 28440221; PMCID: PMC5404919.

6.         Smith-Hicks CL, Cai P, Savonenko AV, Reeves RH, Worley PF. Increased Sparsity of Hippocampal CA1 Neuronal Ensembles in a Mouse Model of Down Syndrome Assayed by Arc Expression. Front Neural Circuits. 2017;11:6. Epub 2017/02/22. doi: 10.3389/fncir.2017.00006. PubMed PMID: 28217086; PMCID: PMC5289947.

7.         Diering GH, Nirujogi RS, Roth RH, Worley PF, Pandey A, Huganir RL. Homer1a drives homeostatic scaling-down of excitatory synapses during sleep. Science. 2017;355(6324):511-5. Epub 2017/02/06. doi: 10.1126/science.aai8355. PubMed PMID: 28154077; PMCID: PMC5382711.

8.         Wang H, Ardiles AO, Yang S, Tran T, Posada-Duque R, Valdivia G, Baek M, Chuang YA, Palacios AG, Gallagher M, Worley P, Kirkwood A. Metabotropic Glutamate Receptors Induce a Form of LTP Controlled by Translation and Arc Signaling in the Hippocampus. J Neurosci. 2016;36(5):1723-9. doi: 10.1523/JNEUROSCI.0878-15.2016. PubMed PMID: 26843652; PMCID: PMC4737780.

9.         Pelkey KA, Barksdale E, Craig MT, Yuan X, Sukumaran M, Vargish GA, Mitchell RM, Wyeth MS, Petralia RS, Chittajallu R, Karlsson RM, Cameron HA, Murata Y, Colonnese MT, Worley PF, McBain CJ. Pentraxins Coordinate Excitatory Synapse Maturation and Circuit Integration of Parvalbumin Interneurons. Neuron. 2016;90(3):661. doi: 10.1016/j.neuron.2016.04.024. PubMed PMID: 27151642.

10.       Na Y, Park S, Lee C, Kim DK, Park JM, Sockanathan S, Huganir RL, Worley PF. Real-Time Imaging Reveals Properties of Glutamate-Induced Arc/Arg 3.1 Translation in Neuronal Dendrites. Neuron. 2016;91(3):561-73. doi: 10.1016/j.neuron.2016.06.017. PubMed PMID: 27397520.

11.       Zhang W, Wu J, Ward MD, Yang S, Chuang YA, Xiao M, Li R, Leahy DJ, Worley PF. Structural basis of arc binding to synaptic proteins: implications for cognitive disease. Neuron. 2015;86(2):490-500. doi: 10.1016/j.neuron.2015.03.030. PubMed PMID: 25864631; PMCID: 4409568.

12.       Marton TM, Hussain Shuler MG, Worley PF. Homer 1a and mGluR5 phosphorylation in reward-sensitive metaplasticity: A hypothesis of neuronal selection and bidirectional synaptic plasticity. Brain research. 2015;1628(Pt A):17-28. doi: 10.1016/j.brainres.2015.06.037. PubMed PMID: 26187757.

13.       Mariga A, Glaser J, Mathias L, Xu D, Xiao M, Worley P, Ninan I, Chao MV. Definition of a Bidirectional Activity-Dependent Pathway Involving BDNF and Narp. Cell reports. 2015;13(9):1747-56. doi: 10.1016/j.celrep.2015.10.064. PubMed PMID: 26655895; PMCID: PMC4681298.

14.       Park JM, Hu JH, Milshteyn A, Zhang PW, Moore CG, Park S, Datko MC, Domingo RD, Reyes CM, Wang XJ, Etzkorn FA, Xiao B, Szumlinski KK, Kern D, Linden DJ, Worley PF. A prolyl-isomerase mediates dopamine-dependent plasticity and cocaine motor sensitization. Cell. 2013;154(3):637-50. doi: 10.1016/j.cell.2013.07.001. PubMed PMID: 23911326; PMCID: 3785238.

15.       Kouser M, Speed HE, Dewey CM, Reimers JM, Widman AJ, Gupta N, Liu S, Jaramillo TC, Bangash M, Xiao B, Worley PF, Powell CM. Loss of predominant Shank3 isoforms results in hippocampus-dependent impairments in behavior and synaptic transmission. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2013;33(47):18448-68. Epub 2013/11/22. doi: 10.1523/JNEUROSCI.3017-13.2013. PubMed PMID: 24259569; PMCID: 3834052.

16.       Gu Y, Huang S, Chang MC, Worley P, Kirkwood A, Quinlan EM. Obligatory Role for the Immediate Early Gene NARP in Critical Period Plasticity. Neuron. 2013;79(2):335-46. Epub 2013/07/31. doi: 10.1016/j.neuron.2013.05.016. PubMed PMID: 23889936.

17.       Ronesi JA, Collins KA, Hays SA, Tsai NP, Guo W, Birnbaum SG, Hu JH, Worley PF, Gibson JR, Huber KM. Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome. Nature neuroscience. 2012;15(3):431-40, S1. Epub 2012/01/24. doi: 10.1038/nn.3033. PubMed PMID: 22267161; PMCID: 3288402.

18.       Okuno H, Akashi K, Ishii Y, Yagishita-Kyo N, Suzuki K, Nonaka M, Kawashima T, Fujii H, Takemoto-Kimura S, Abe M, Natsume R, Chowdhury S, Sakimura K, Worley PF, Bito H. Inverse synaptic tagging of inactive synapses via dynamic interaction of Arc/Arg3.1 with CaMKIIbeta. Cell. 2012;149(4):886-98. Epub 2012/05/15. doi: 10.1016/j.cell.2012.02.062. PubMed PMID: 22579289.

19.       Hu JH, Yang L, Kammermeier PJ, Moore CG, Brakeman PR, Tu J, Yu S, Petralia RS, Li Z, Zhang PW, Park JM, Dong X, Xiao B, Worley PF. Preso1 dynamically regulates group I metabotropic glutamate receptors. Nature neuroscience. 2012;15(6):836-44. Epub 2012/05/09. doi: 10.1038/nn.3103. PubMed PMID: 22561452; PMCID: 3434267.

20.       Wu J, Petralia RS, Kurushima H, Patel H, Jung MY, Volk L, Chowdhury S, Shepherd JD, Dehoff M, Li Y, Kuhl D, Huganir RL, Price DL, Scannevin R, Troncoso JC, Wong PC, Worley PF. Arc/Arg3.1 regulates an endosomal pathway essential for activity-dependent beta-amyloid generation. Cell. 2011;147(3):615-28. Epub 2011/11/01. doi: 10.1016/j.cell.2011.09.036. PubMed PMID: 22036569; PMCID: 3207263.

21.       Zou J, Zhou L, Du XX, Ji Y, Xu J, Tian J, Jiang W, Zou Y, Yu S, Gan L, Luo M, Yang Q, Cui Y, Yang W, Xia X, Chen M, Zhao X, Shen Y, Chen PY, Worley PF, Xiao B. Rheb1 is required for mTORC1 and myelination in postnatal brain development. Dev Cell. 2011;20(1):97-108. Epub 2011/01/18. doi: 10.1016/j.devcel.2010.11.020. PubMed PMID: 21238928; PMCID: 3056331.

22.       Smith-Hicks C, Xiao B, Deng R, Ji Y, Zhao X, Shepherd JD, Posern G, Kuhl D, Huganir RL, Ginty DD, Worley PF, Linden DJ. SRF binding to SRE 6.9 in the Arc promoter is essential for LTD in cultured Purkinje cells. Nature neuroscience. 2010;13(9):1082-9. Epub 2010/08/10. doi: 10.1038/nn.2611. PubMed PMID: 20694003; PMCID: 3003596.

23.       Hu JH, Park JM, Park S, Xiao B, Dehoff MH, Kim S, Hayashi T, Schwarz MK, Huganir RL, Seeburg PH, Linden DJ, Worley PF. Homeostatic scaling requires group I mGluR activation mediated by Homer1a. Neuron. 2010;68(6):1128-42. Epub 2010/12/22. doi: 10.1016/j.neuron.2010.11.008. PubMed PMID: 21172614; PMCID: 3013614.

24.       Chang MC, Park JM, Pelkey KA, Grabenstatter HL, Xu D, Linden DJ, Sutula TP, McBain CJ, Worley PF. Narp regulates homeostatic scaling of excitatory synapses on parvalbumin-expressing interneurons. Nature neuroscience. 2010;13(9):1090-7. doi: 10.1038/nn.2621. PubMed PMID: 20729843; PMCID: 2949072.