Paul Worley MD

Professor of Neuroscience




For a more complete list of publications, click here.

Zhou, J., Y. Chuang, J. Redding-Ochoa, R. Zhang, A. J. Platero, A. H. Barrett, J. C. Troncoso, P. F. Worley and W. Zhang (2024). "The autophagy adaptor TRIAD3A promotes tau fibrillation by nested phase separation." Nat Cell Biol.


Soldan, A., S. Oh, T. Ryu, C. Pettigrew, Y. Zhu, A. Moghekar, M. F. Xiao, G. M. Pontone, M. Albert, C. H. Na and P. Worley (2023). "NPTX2 in cerebrospinal fluid predicts the progression from normal cognition to Mild Cognitive Impairment." Ann Neurol.


Zhou, J., S. D. Wade, D. Graykowski, M. F. Xiao, B. Zhao, L. A. A. Giannini, J. E. Hanson, J. C. van Swieten, M. Sheng, P. F. Worley and B. Dejanovic (2023). "The neuronal pentraxin Nptx2 regulates complement activity and restrains microglia-mediated synapse loss in neurodegeneration." Sci Transl Med 15(689): eadf0141.


Yang, L., W. Liu, L. Shi, J. Wu, W. Zhang, Y. A. Chuang, J. Redding-Ochoa, A. Kirkwood, A. V. Savonenko and P. F. Worley (2023). "NMDAR-Arc signaling is required for Memory Updating and is disrupted in Alzheimer's Disease." Biol Psychiatry.


Huang, H., B. Jing, F. Zhu, W. Jiang, P. Tang, L. Shi, H. Chen, G. Ren, S. Xia, L. Wang, Y. Cui, Z. Yang, A. J. Platero, A. P. Hutchins, M. Chen, P. F. Worley and B. Xiao (2023). "Disruption of neuronal RHEB signaling impairs oligodendrocyte differentiation and myelination through mTORC1-DLK1 axis." Cell Rep 42(7): 112801.


Yu, Z., Z. Yang, G. Ren, Y. Wang, X. Luo, F. Zhu, S. Yu, L. Jia, M. Chen, P. F. Worley and B. Xiao (2022). "GATOR2 complex-mediated amino acid signaling regulates brain myelination." Proc Natl Acad Sci U S A 119(3).


Yang, W., D. Pang, M. Chen, C. Du, L. Jia, L. Wang, Y. He, W. Jiang, L. Luo, Z. Yu, M. Mao, Q. Yuan, P. Tang, X. Xia, Y. Cui, B. Jing, A. Platero, Y. Liu, Y. Wei, P. F. Worley and B. Xiao (2021). "Rheb mediates neuronal-activity-induced mitochondrial energetics through mTORC1-independent PDH activation." Dev Cell 56(6): 811-825 e816.


Severin, D., S. Z. Hong, S. E. Roh, S. Huang, J. Zhou, M. C. D. Bridi, I. Hong, S. Murase, S. Robertson, R. P. Haberman, R. L. Huganir, M. Gallagher, E. M. Quinlan, P. Worley and A. Kirkwood (2021). "All-or-none disconnection of pyramidal inputs onto parvalbumin-positive interneurons gates ocular dominance plasticity." Proc Natl Acad Sci U S A 118(37).


Xiao, M. F., S. E. Roh, J. Zhou, C. C. Chien, B. P. Lucey, M. T. Craig, L. N. Hayes, J. M. Coughlin, F. M. Leweke, M. Jia, D. Xu, W. Zhou, C. Conover Talbot, Jr., D. B. Arnold, M. Staley, C. Jiang, I. M. Reti, A. Sawa, K. A. Pelkey, C. J. McBain, A. Savonenko and P. F. Worley (2021). "A biomarker-authenticated model of schizophrenia implicating NPTX2 loss of function." Sci Adv 7(48): eabf6935.


Xiao, M. F., D. Xu, M. T. Craig, K. A. Pelkey, C. C. Chien, Y. Shi, J. Zhang, S. Resnick, O. Pletnikova, D. Salmon, J. Brewer, S. Edland, J. Wegiel, B. Tycko, A. Savonenko, R. H. Reeves, J. C. Troncoso, C. J. McBain, D. Galasko and P. F. Worley (2017). "NPTX2 and cognitive dysfunction in Alzheimer's Disease." Elife 6.