Thu 31st October 2013

The Huganir lab reports in Science

The Huganir lab reports in Science the discovery of a candidate gene linking synapse formation and language development.  SRPX2 was a secreted protein identified in a high throughput screen for synaptogenic molecules.  SRPX2 promotes excitatory synapse formation under the control of the language-associated transcription factor FOXP2. Loss of SRPX2 impairs synapse formation and ultrasonic vocalization in mice, indicating that this may represent a pathway crucial for circuit formation underlying language development.

Sia, G.M., Clem, R. L., Huganir, R.L.  (2013) The human language-associated gene SRPX2 regulates synapse formation and vocalization in mice. Science 2013: Vol. 342 no. 6161 pp. 987-991; DOI: 10.1126/science.1245079

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