David Yue and colleagues report in the the current issue of Cell a surprising role for Ca2+-unbound apopcalmodulin in regulating calcium and sodium channel activities. The Ca2+-free form of calmodulin (apoCaM) often appears inert, modulating target molecules only upon conversion to its Ca2+-bound form. This schema has appeared to govern voltage-gated Ca2+ channels, where apoCaM has been considered a dormant Ca2+ sensor, associated with channels but awaiting the binding of Ca2+ io...

David Yue and colleagues report in the the current issue of Cell a surprising role for Ca2+-unbound apopcalmodulin in regulating calcium and sodium channel activities. The Ca2+-free form of calmodulin (apoCaM) often appears inert, modulating target molecules only upon conversion to its Ca2+-bound form. This schema has appeared to govern voltage-gated Ca2+ channels, where apoCaM has been considered a dormant Ca2+ sensor, associated with channels but awaiting the binding of Ca2+ io...

Richard Huganir, Ph.D., has received the Goldman-Rakic Prize for Outstanding Achievement in Cognitive Neuroscience from the Brain & Behavior Research Foundation. The $40,000 prize is named for pioneering neurobiologist Patricia Goldman-Rakic. The award recognizes significant contributions made at the cellular, physiological or behavioral levels that may lend new insight into psychiatric and neurological disease. As a recipient, Huganir will be invited to give an honorary lect...

Richard Huganir, Ph.D., has received the Goldman-Rakic Prize for Outstanding Achievement in Cognitive Neuroscience from the Brain & Behavior Research Foundation. The $40,000 prize is named for pioneering neurobiologist Patricia Goldman-Rakic. The award recognizes significant contributions made at the cellular, physiological or behavioral levels that may lend new insight into psychiatric and neurological disease. As a recipient, Huganir will be invited to give an honorary lect...