The Kolodkin lab reports in Science that signaling between the transmembrane guidance cue semaphorin 6A (Sema6A) and its receptor plexinA2 (PlexA2) regulates dendritic morphology of On, but not Off, starburst amacrine cells, thereby controlling direction-selective responses to visual stimuli in the mouse.
Direction-selective responses to visual cues depend upon precise connectivity between inhibitory starburst amacrine cells (SACs) and direction-selective ganglion cells (DSGCs). Mot...