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Wed 3rd July 2024
Navigating in the Dark: New Research from Knierim and Cowan
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Tue 19th March 2024
Dr. Huganir's latest research in Science
Dr. Huganir's latest research on SynGAP appears in the latest issue of Science! This vital synaptic protein has an additional surpising role as a scaffold to regulate PSD-95 availability. Check it out!
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Thu 1st October 2020
Blackshaw lab unlocks hidden regenerative potential in mammalian retina
The lab of Dr. Seth Blackshaw Professor of Neuroscience in the Solomon H. Snyder Department of Neuroscience published a paper in Science that maps out the network of genes that controls the ability of retinal neurons to regenerate from glial support cells.
The paper’s lead authors, Thanh Hoang and Jie Wang, comprehensively analyzed changes in gene action that occur in retinal glial cells following injury three species – zebrafish, chickens and mice – which differ in their ability to generate retinal neurons in response to injury. Zebrafish can robustly regenerate neurons, newly hatched chicks can do so weakly and mice, like humans, cannot do so at all. This study found that retinal glial cells from all three species transition to an activated stage following injury, and that this is required for glia to be able to generate neurons in zebrafish and chicks, but identified a gene regulatory network in mice that actively blocked this process. By inactivating NFI family transcription factors, which are part of this network, Blackshaw’s group was able to induce mouse glia to generate retinal neurons. This demonstrates that mammals possess a latent ability to regenerate neurons lost to injury and disease, and that this can be awakened by disrupting genes in this network. This approach may be useful in cell-based therapies aimed at restoring retinal neurons lost due to blinding diseases.
Gene regulatory networks controlling vertebrate retinal regeneration
Science 01 Oct 2020
https://science.sciencemag.org/content/early/2020/09/30/science.abb8598
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Tue 22nd October 2019
Publications - October 2019
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Tue 22nd October 2019
The Potter Lab investigates how common insect repellents affect a mosquito's nose
Congratulations to Dr. Christopher Potter, a Primary member in the Neuroscience Department, and his lab for uncovering how commonly used insect repellents such as DEET interfere with an Anopheles mosquito's sense of smell. Their recent work now appears in Current Biology.
Afify A, Betz JF, Riabinina O, Lahondère C, Potter CJ (2019). Commonly used insect repellents hide human odors from Anopheles mosquitoes. Current Biology. DOI:10.1016/j.cub.2019.09.007.
https://www.cell.com/current-biology/fulltext/S0960-9822(19)31167-4.
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Mon 30th September 2019
Publications - September 2019
Publications from Primary Faculty members - September 2019:
Chokshi V, Gao M, Grier BD Owens A Wang H, Worley PF Lee HK. Input-Specific Metaplasticity in the Visual Cortex Requires Homer1a-Mediated mGluR5 Signaling. Neuron. 2019 Sep 5. pii: S0896-6273(19)30701-9. doi: 10.1016/j.neuron.2019.08.017. [Epub ahead of print]
Frandolig JE, Matney CJ, Lee K, Kim J, Chevée M, Kim SJ, Bickert AA, Brown SP. The Synaptic Organization of Layer 6 Circuits Reveals Inhibition as a Major Output of a Neocortical Sublamina. Cell Rep. 2019 Sep 17;28(12):3131-3143.e5. doi: 10.1016/j.celrep.2019.08.048.
Xie X, Tabuchi M, Corver A, Duan G, Wu MN, Kolodkin AL. Semaphorin 2b Regulates Sleep-Circuit Formation in the Drosophila Central Brain. Neuron. 2019 Sep 26. pii: S0896-6273(19)30645-2. doi: 10.1016/j.neuron.2019.07.019. [Epub ahead of print]
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Mon 19th August 2019
Publications - August 2019
Publications from Primary Faculty members - August 2019:
Dunn-Weiss E, Nummela SU, Lempel AA, Law J, Ledley J, Salvino P, Nielsen KJ. Visual motion and form integration in the behaving ferret. eNeuro.2019 Aug 1. pii: ENEURO.0228-19.2019. doi: 10.1523/ENEURO.0228-19.2019. [Epub ahead of print]
Rodriguez G, Mesik L, Gao M, Parkins S, Saha R, Lee HK. Disruption of NMDA receptor function prevents normal experience-dependent homeostatic synaptic plasticity in mouse primary visual cortex. J Neurosci. 2019 Aug 14. pii: 2117-18. doi: 10.1523/JNEUROSCI.2117-18.2019. [Epub ahead of print]
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Mon 5th August 2019
The Doetlzhofer Lab Investigates Proteins That Might Restore Damaged Sound-Detecting Cells in The Ear
Congratulations to Dr. Doetzlhofer (primary member in the Neuroscience Department) and her lab for uncovering key players in cochlear hair cell differentiation! Their recent work now appears in eLife.
A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea
Meenakshi Prajapati-DiNubila, Ana Benito-Gonzalez, Erin Jennifer Golden, Shuran Zhang, Angelika Doetzlhofer
eLife 2019;8:e47613
https://doi.org/10.7554/eLife.47613
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Fri 26th July 2019
The Cohen lab defines a stable neural mechanism to drive flexible behavior
Congratulations to Dr. Jeremiah Cohen, Assistant Professor in the Solomon H. Snyder Department of Neuroscience and Brain Science Institute, and his lab for their recent work published in Neuron examining the medial prefontal cortex's role in encoding value-based decision variables.
Neuron article:
"Stable Representations of Decision Variables for Flexible Behavior"
Bilal A.Bari, Cooper D.Grossman, Emily E.Lubin, Adithya E.Rajagopalan, Jianna I.Cressy, Jeremiah Y.Cohen.
https://www.sciencedirect.com/science/article/pii/S089662731930529X
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Tue 23rd July 2019
Publications - July 2019
Publications from Primary Faculty members - July 2019:
Fraser KM, Janak PH. Occasion setters attain incentive motivational value: implications for contextual influences on reward-seeking. Learn Mem. 2019 Jul 15;26(8):291-298. doi: 10.1101/lm.049320.119. Print 2019 Aug.
Pundir P, Liu R, Vasavda C, Serhan N, Limjunyawong N, Yee R, Zhan Y, Dong X, Wu X, Zhang Y, Snyder SH, Gaudenzio N, Vidal JE, Dong X. A Connective Tissue Mast-Cell-Specific Receptor Detects Bacterial Quorum-Sensing Molecules and Mediates Antibacterial Immunity. Cell Host Microbe. 2019 Jul 10;26(1):114-122.e8. doi: 10.1016/j.chom.2019.06.003. Epub 2019 Jul 2.
Vasavda C, Kothari R, Malla AP, Tokhunts R, Lin A, Ji M, Ricco C, Xu R, Saavedra HG, Sbodio JI, Snowman AM, Albacarys L, Hester L, Sedlak TW, Paul BD, Snyder SH. Bilirubin Links Heme Metabolism to Neuroprotection by Scavenging Superoxide. Cell Chem Biol. 2019 Jul 23. pii: S2451-9456(19)30218-1. doi: 10.1016/j.chembiol.2019.07.006. [Epub ahead of print]
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Tue 16th April 2019
Publications - April 2019
Publications from Primary Faculty members - April 2019:
Miller SJ, Philips T, Kim N, Dastgheyb R, Chen Z, Hsieh YC, Daigle JG, Datta M, Chew J, Vidensky S, Pham JT, Hughes EG, Robinson MB, Sattler R, Tomer R, Suk JS, Bergles DE, Haughey N, Pletnikov M, Hanes J, Rothstein JD. Molecularly defined cortical astroglia subpopulation modulates neurons via secretion of Norrin. Nat Neurosci. 2019 Apr 1. doi: 10.1038/s41593-019-0366-7. [Epub ahead of print].
Nardou R, Lewis EM, Rothhaas R, Xu R, Yang A, Boyden E, Dölen G. Oxytocin-dependent reopening of a social reward learning critical period with MDMA. Nature. 2019 Apr 3. doi: 10.1038/s41586-019-1075-9. [Epub ahead of print]
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Sun 31st March 2019
Publication - March 2019
Publications from Primary Faculty members - March 2019:
Chokshi V, Druciak B, Worley PF, Lee HK. Homer1a is required for establishment of contralateral bias and maintenance of ocular dominance in mouse visual cortex. J Neurosci. 2019 Mar 13. pii: 3188-18. doi: 10.1523/JNEUROSCI.3188-18.2019. [Epub ahead of print]
Weyemi U, Paul BD, Bhattacharya D, Malla AP, Boufraqech M, Harraz MM, Bonner WM, Snyder SH. Histone H2AX promotes neuronal health by controlling mitochondrial homeostasis. Proc Natl Acad Sci U S A. 2019 Apr 9;116(15):7471-7476. doi: 10.1073/pnas.1820245116. Epub 2019 Mar 25.
Yoo S, Cha D, Kim DW, Hoang TV, Blackshaw S. Tanycyte-Independent Control of Hypothalamic Leptin Signaling. Front Neurosci. 2019 Mar 19;13:240. doi: 10.3389/fnins.2019.00240. eCollection 2019.
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Wed 27th February 2019
Publications - February 2019
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Tue 12th February 2019
The Knierim Lab Reveals How the Brain Keeps Track of Location
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Wed 23rd January 2019
Publications - January 2019
Publications from Primary Faculty members - January 2019:
Andzelm MM, Vanness D, Greenberg ME, Linden DJ. A Late Phase of Long-Term Synaptic Depression in Cerebellar Purkinje Cells Requires Activation of MEF2. Cell Rep. 2019 Jan 29;26(5):1089-1097.e3. doi: 10.1016/j.celrep.2019.01.004.
Green DP, Limjunyawong N, Gour N, Pundir P, Dong X. A Mast-Cell-Specific Receptor Mediates Neurogenic Inflammation and Pain. Neuron. 2019 Feb 6;101(3):412-420.e3. doi: 10.1016/j.neuron.2019.01.012. Epub 2019 Jan 24.
Keiflin R, Pribut HJ, Shah NB, Janak PH. Ventral Tegmental Dopamine Neurons Participate in Reward Identity Predictions. Curr Biol. 2019 Jan 7;29(1):93-103.e3. doi: 10.1016/j.cub.2018.11.050. Epub 2018 Dec 20. Proc Natl Acad Sci U S A. 2019 Jan 7. pii: 201811259. doi: 10.1073/pnas.1811259115. [Epub ahead of print]
Meixiong J, Vasavda C, Green D, Zheng Q, Qi L, Kwatra SG, Hamilton JP, Snyder SH, Dong X. Identification of a bilirubin receptor that may mediate a component of cholestatic itch. Elife. 2019 Jan 18;8. pii: e44116. doi: 10.7554/eLife.44116. [Epub ahead of print]
Sacré P, Kerr MSD, Subramanian S, Fitzgerald Z, Kahn K, Johnson MA, Niebur E, Eden UT, González-Martínez JA, Gale JT, Sarma SV. Risk-taking bias in human decision-making is encoded via a right-left brain push-pull system. Proc Natl Acad Sci U S A. 2019 Jan 7. pii: 201811259. doi: 10.1073/pnas.1811259115. [Epub ahead of print]
Sedlak TW, Paul BD, Parker GM, Hester LD, Snowman AM, Taniguchi Y, Kamiya A, Snyder SH, Sawa A. The glutathione cycle shapes synaptic glutamate activity. Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2701-2706. doi: 10.1073/pnas.1817885116. Epub 2019 Jan 28.
Shah AP, Johnson MD, Fu X, Boersma GJ, Shah M, Wolfgang MJ, Tamashiro KL, Baraban JM. Deletion of translin (Tsn) induces robust adiposity and hepatic steatosis without impairing glucose tolerance. Int J Obes (Lond). 2019 Jan 15. doi: 10.1038/s41366-018-0315-7. [Epub ahead of print]
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Mon 7th January 2019
Collaborative Study between Hopkins Neuroscience and Biomedical Engineering Reveals Insights into How Humans Make Decisions
Why do people make high-risk decisions, even against the odds? Johns Hopkins researchers say bias that develops over time may make people view risk differently. (Image Credit: Jennifer E. Fairman, CMI, FAMI. © 2019, Johns Hopkins University, AAM)
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Mon 31st December 2018
Publications - December 2018
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Tue 27th November 2018
Knierim Lab Discovers New Role for Brain Region Critical for Memory
The lab of Professor of Neuroscience James Knierim in the Zanvyl Krieger Mind/Brain Institute published a paper in Science that discovered a new role of the Lateral Entorhinal Cortex (LEC)—one of the gateways of information into the hippocampal memory system. The paper’s lead authors, Cheng Wang and Xiaojing Chen, showed that the LEC encodes experience from a first-person (egocentric) perspective, in contrast to the world-centered (allocentric) coding of place cells, grid cells, and head direction cells. This discovery supports the idea that the LEC conveys information about the sensory content of an organisms’ experience, which the hippocampus binds within the allocentric maps provided by grid cells and place cells to form the basis of an episodic memory of an event within its spatiotemporal context.
Link to article: http://science.sciencemag.org/content/362/6417/945.long
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Wed 31st October 2018
Publications - October 2018
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Sun 21st October 2018
Study by Dr. Janak Identifies Ventral Pallidum as Food Reward Center
Working with rats, researchers have found robust neural activity related to food choice in a previously overlooked part of the brain. The findings, published in the journal Nature Communications, suggest this brain area could be key to developing therapies and treatments to encourage healthy eating.
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Sun 30th September 2018
Publications - September 2018
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Fri 21st September 2018
Dr. Stuphorn Finds Brain Center Linked to High-Risk Behavior
GAMBLING MONKEYS LIKE BIG BETS, STUDY FINDS
Scientists locate area of brain linked to high-risk behavior, a possible step toward improved treatments for destructively risky behaviors in humans
Monkeys who learned how to gamble have helped researchers pinpoint an area of the brain key to one's willingness to make risky decisions.
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Thu 20th September 2018
Dr. Dölen Publishes Study Suggesting Octopuses Moods are Influenced by drug Ectasy
By studying the genome of a kind of octopus not known for its friendliness toward its peers, then testing its behavioral reaction to a popular mood-altering drug called MDMA or “ecstasy,” scientists say they have found preliminary evidence of an evolutionary link between the social behaviors of the sea creature and humans, species separated by 500 million years on the evolutionary tree.
A summary of the experiments is published Sept. 20 in Current Biology, and if the findings are validated, the researchers say, they may open opportunities for accurately studying the impact of psychiatric drug therapies in many animals distantly related to people.
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Thu 23rd August 2018
Publications - August 2018
Publications for Primary Faculty Members - August 2018:
Babola TA, Li S, Gribizis A, Lee BJ, Issa JB, Wang HC, Crair MC, Bergles DE. Homeostatic Control of Spontaneous Activity in the Developing Auditory System. Neuron. 2018 Aug 8;99(3):511-524.e5. doi: 10.1016/j.neuron.2018.07.004. Epub 2018 Aug 1.
Cherry-Allen KM, Statton MA, Celnik PA, Bastian AJ.A Dual-Learning Paradigm Simultaneously Improves Multiple Features of Gait Post-Stroke. Neurorehabil Neural Repair. 2018 Aug 7:1545968318792623. doi: 10.1177/1545968318792623. [Epub ahead of print]
Chin SG, Maguire SE, Huoviala P, Jefferis GSXE, Potter CJ. Olfactory Neurons and Brain Centers Directing Oviposition Decisions in Drosophila. Cell Rep. 2018 Aug 7;24(6):1667-1678. doi: 10.1016/j.celrep.2018.07.018.
Lilley BN, Sabbah S, Hunyara JL, Gribble KD, Al-Khindi T, Xiong J, Wu Z, Berson DM, Kolodkin AL. Genetic access to neurons in the accessory optic system reveals a role for Sema6A in midbrain circuitry mediating motion perception. J Comp Neurol. 2018 Aug 3. doi: 10.1002/cne.24507. [Epub ahead of print]
Newman EA, Wu D, Taketo MM, Zhang J, Blackshaw S. Canonical Wnt signaling regulates patterning, differentiation and nucleogenesis in mouse hypothalamus and prethalamus. Dev Biol. 2018 Jul 29. pii: S0012-1606(18)30451-2. doi: 10.1016/j.ydbio.2018.07.021. [Epub ahead of print]
Saunders BT, Richard JM, Margolis EB, Janak PH. Dopamine neurons create Pavlovian conditioned stimuli with circuit-defined motivational properties. Nat Neurosci. 2018 Aug;21(8):1072-1083. doi: 10.1038/s41593-018-0191-4. Epub 2018 Jul 23.
Sun S, Babola T, Pregernig G, So KS, Nguyen M, Su SM, Palermo AT, Bergles DE, Burns JC, Müller U. Hair Cell Mechanotransduction Regulates Spontaneous Activity and Spiral Ganglion Subtype Specification in the Auditory System. Cell. 2018 Jul 30. pii: S0092-8674(18)30902-4. doi: 10.1016/j.cell.2018.07.008. [Epub ahead of print]
Therrien AS, Wolpert DM, Bastian AJ. Increasing Motor Noise Impairs Reinforcement Learning in Healthy Individuals. eNeuro. 2018 Aug 13;5(3). pii: ENEURO.0050-18.2018. doi: 10.1523/ENEURO.0050-18.2018. eCollection 2018 May-Jun.
Zimmet AM, Cowan NJ, Bastian AJ. Patients with Cerebellar Ataxia Do Not Benefit from Limb Weights. Cerebellum. 2018 Aug 1. doi: 10.1007/s12311-018-0962-1. [Epub ahead of print]
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Sun 20th May 2018
Publications - May 2018
Publications from Primary Faculty Members - May 2018:
Bridi MCD, de Pasquale R, Lantz CL, Gu Y, Borrell A, Choi SY, He K, Tran T, Hong SZ, Dykman A, Lee HK, Quinlan EM, Kirkwood A. Two distinct mechanisms for experience-dependent homeostasis. Nat Neurosci. 2018 May 14. doi: 10.1038/s41593-018-0150-0. [Epub ahead of print]
Chen X, Knierim J. It's About Time: Temporal Dynamics of Dentate Gyrus Pattern Separation. Neuron. 2018 May 16;98(4):681-683. doi: 10.1016/j.neuron.2018.05.007.
Fu C, Rojas T, Chin AC, Cheng W, Bernstein IA, Albacarys LK, Wright WW, Snyder SH. Multiple aspects of male germ cell development and interactions with Sertoli cells require inositol hexakisphosphate kinase-1. Sci Rep. 2018 May 4;8(1):7039. doi: 10.1038/s41598-018-25468-8.
Li RC, Lin CC, Ren X, Wu JS, Molday LL, Molday RS, Yau KW. Ca2+-activated Cl current predominates in threshold response of mouse olfactory receptor neurons. Proc Natl Acad Sci U S A. 2018 May 7. pii: 201803443. doi: 10.1073/pnas.1803443115. [Epub ahead of print]
Minamisawa G, Kwon SE, Chevée M, Brown SP, O'Connor DH. A Non-canonical Feedback Circuit for Rapid Interactions between Somatosensory Cortices. Cell Rep. 2018 May 29;23(9):2718-2731.e6. doi: 10.1016/j.celrep.2018.04.115.
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Wed 25th April 2018
Publications - April 2018
Publications from Primary Faculty Members - April 2018:
de Melo J, Clark BS, Venkataraman A, Shiau F, Zibetti C, Blackshaw S. Ldb1 and Rnf12-dependent regulation of Lhx2 controls the relative balance between neurogenesis and gliogenesis in retina. Development. 2018 Apr 12. pii: dev.159970. doi: 10.1242/dev.159970. [Epub ahead of print]
Heo S, Diering GH, Na CH, Nirujogi RS, Bachman JL, Pandey A, Huganir RL. Identification of long-lived synaptic proteins by proteomic analysis of synaptosome protein turnover. Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):E3827-E3836. doi: 10.1073/pnas.1720956115. Epub 2018 Apr 2.
Newman EA, Kim DW, Wan J, Wang J, Qian J, Blackshaw S. Foxd1 is required for terminal differentiation of anterior hypothalamic neuronal subtypes. Dev Biol. 2018 Apr 18. pii: S0012-1606(17)30906-5. doi: 10.1016/j.ydbio.2018.04.012. [Epub ahead of print]
Weyemi U, Paul BD, Snowman AM, Jailwala P, Nussenzweig A, Bonner WM, Snyder SH. Histone H2AX deficiency causes neurobehavioral deficits and impaired redox homeostasis. Nat Commun. 2018 Apr 18;9(1):1526. doi: 10.1038/s41467-018-03948-9.
Xie T, Ho MC, Liu Q, Horiuchi W, Lin CC, Task D, Luan H, White BH, Potter CJ, Wu MN. A Genetic Toolkit for Dissecting Dopamine Circuit Function in Drosophila. Cell Rep. 2018 Apr 10;23(2):652-665. doi: 10.1016/j.celrep.2018.03.068.
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Mon 2nd April 2018
The Huganir Lab Reports in PNAS the Identification of Long-Lived Proteins in Synaptosomes
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Sat 31st March 2018
Publications - March 2018
Publications from Primary Faculty Members - March 2018:
Day KA, Leech KA, Roemmich RT, Bastian AJ. Accelerating locomotor savings in learning: compressing four training days to one. J Neurophysiol. 2018 Mar 14. doi: 10.1152/jn.00903.2017. [Epub ahead of print]
Hughes EG, Orthmann-Murphy JL, Langseth AJ, Bergles DE. Myelin remodeling through experience-dependent oligodendrogenesis in the adult somatosensory cortex. Nat Neurosci. 2018 Mar 19. doi: 10.1038/s41593-018-0121-5. [Epub ahead of print]
Kornberg MD, Bhargava P, Kim PM, Putluri V, Snowman AM, Putluri N, Calabresi PA, Snyder SH. Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity. Science. 2018 Mar 29. pii: eaan4665. doi: 10.1126/science.aan4665. [Epub ahead of print]
Larson VA, Mironova Y, Vanderpool KG, Waisman A, Rash JE, Agarwal A, Bergles DE. Oligodendrocytes control potassium accumulation in white matter and seizure susceptibility. Oligodendrocytes control potassium accumulation in white matter and seizure susceptibility. Elife. 2018 Mar 29;7. pii: e34829. doi: 10.7554/eLife.34829.
Richard JM, Stout N, Acs D, Janak PH. Ventral pallidal encoding of reward-seeking behavior depends on the underlying associative structure. Elife. 2018 Mar 22;7. pii: e33107. doi: 10.7554/eLife.33107.
Sbodio JI, Snyder SH, Paul BD. REDOX MECHANISMS IN NEURODEGENERATION: FROM DISEASE OUTCOMES TO THERAPEUTIC OPPORTUNITIES. Antioxid Redox Signal. 2018 Mar 21. doi: 10.1089/ars.2017.7321. [Epub ahead of print]
Venkataraman A, Yang K, Irizarry J, Mackiewicz M, Mita P, Kuang Z, Xue L, Ghosh D, Liu S, Ramos P, Hu S, Bayron Kain D, Keegan S, Saul R, Colantonio S, Zhang H, Behn FP, Song G, Albino E, Asencio L, Ramos L, Lugo L, Morell G, Rivera J, Ruiz K, Almodovar R, Nazario L, Murphy K, Vargas I, Rivera-Pacheco ZA, Rosa C, Vargas M, McDade J, Clark BS, Yoo S, Khambadkone SG, de Melo J, Stevanovic M, Jiang L, Li Y, Yap WY, Jones B, Tandon A, Campbell E, Montelione GT, Anderson S, Myers RM, Boeke JD, Fenyö D, Whiteley G, Bader JS, Pino I, Eichinger DJ, Zhu H, Blackshaw S. A toolbox of immunoprecipitation-grade monoclonal antibodies to human transcription factors. Nat Methods. 2018 Mar 19. doi: 10.1038/nmeth.4632. [Epub ahead of print]
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Thu 15th February 2018
Publications - February 2018
Publications from Primary Faculty Members - February 2018:
Han L, Limjunyawong N, Ru F, Li Z, Hall OJ, Steele H, Zhu Y, Wilson J, Mitzner W, Kollarik M, Undem BJ, Canning BJ, Dong X. Mrgprs on vagal sensory neurons contribute to bronchoconstriction and airway hyper-responsiveness. Nat Neurosci. 2018 Feb 5. doi: 10.1038/s41593-018-0074-8. [Epub ahead of print]
Sasikumar D, Emeric E, Stuphorn V, Connor CE. First-Pass Processing of Value Cues in the Ventral Visual Pathway. Curr Biol. 2018 Feb 19;28(4):538-548.e3. doi: 10.1016/j.cub.2018.01.051. Epub 2018 Feb 8.
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Mon 22nd January 2018
Publications - January 2018
Publications from Primary Faculty Members - January 2018:
Chevée M, Robertson JJ, Cannon GH, Brown SP, Goff LA. Variation in Activity State, Axonal Projection, and Position Define the Transcriptional Identity of Individual Neocortical Projection Neurons. Cell Rep. 2018 Jan 9;22(2):441-455. doi: 10.1016/j.celrep.2017.12.046.
Finkel, EA, O'Connor, DH. Learning Recruits Higher Cortical Areas into Rapid Sensorimotor Streams. Neuron. 2018 Jan 3;97(1):1-2. doi: 10.1016/j.neuron.2017.12.026.
Leech, KA, Roemmich, RT, Bastina, AJ. Creating flexible motor memories in human walking.Sci Rep. 2018 Jan 8;8(1):94. doi: 10.1038/s41598-017-18538-w.
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Mon 11th December 2017
Publications - December 2017
Publications from Primary Faculty Members - December 2017:
Fischbach-Weiss, S, Reese, RM, Janak, PH. Inhibiting Mesolimbic Dopamine Neurons Reduces the Initiation and Maintenance of Instrumental Responding. Neuroscience. 2017 Dec 15. pii: S0306-4522(17)30874-6. doi: 10.1016/j.neuroscience.2017.12.003. [Epub ahead of print]
Fu C, Tyagi R, Chin AC, Rojas T, Li RJ, Guha P, Bernstein IA, Rao F, Xu R, Cha JY, Xu J, Snowman AM, Semenza GL, Snyder SH. Inositol Polyphosphate Multikinase Inhibits Angiogenesis via Inositol Pentakisphosphate-Induced HIF-1α Degradation. Circ Res. 2017 Dec 26. pii: CIRCRESAHA.117.311983. doi: 10.1161/CIRCRESAHA.117.311983. [Epub ahead of print]
Paul, BD, Snyder, SH. Gasotransmitter Hydrogen Sulfide Signaling in Neuronal Health and Disease. Biochem Pharmacol. 2017 Dec 1. pii: S0006-2952(17)30700-1. doi: 10.1016/j.bcp.2017.11.019. [Epub ahead of print]
Piard J, Hu JH, Campeau PM, Rzonca S, Van Esch H, Vincent E, Han M, Rossignol E, Castaneda J, Chelly J, Skinner C, Kalscheuer VM10, Wang R, Lemyre E, Kosinska J, Stawinski P, Bal J, Hoffman DA, Schwartz CE, Van Maldergem L, Wang T, Worley P. FRMPD4 Mutations Cause X-linked Intellectual Disability and Disrupt Dendritic Spine Morphogenesis. Hum Mol Genet. 2017 Dec 18. doi: 10.1093/hmg/ddx426. [Epub ahead of print]
Scherer, PC, Zaccor, NW, Neumann, NM, Vasavda, C, Barrow, R, Ewald, AJ, Rao, F, Sumner, CJ, Snyder, SH. TRPV1 is a physiological regulator of μ-opioid receptors. Proc Natl Acad Sci U S A. 2017 Dec 4. pii: 201717005. doi: 10.1073/pnas.1717005114. [Epub ahead of print]
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Mon 27th November 2017
Publication - November 2017
Publications from Primary Faculty Members - November 2017:
Hu, B, Niebur, E. A recurrent neural model for proto-object based contour integration and figure-ground segregation. J Comput Neurosci. 2017 Dec;43(3):227-242. doi: 10.1007/s10827-017-0659-3. Epub 2017 Sep 19.
Meixiong, J, Dong, X. Mas-Related G Protein-Coupled Receptors and the Biology of Itch Sensation. Annu Rev Genet. 2017 Nov; 51: 103-121. . doi: 10.1146/annurev-genet-120116-024723.
Wang Q, Chiu SL, Koropouli E, Hong I, Mitchell S, Easwaran TP, Hamilton NR, Gustina AS, Zhu Q, Ginty DD, Huganir RL, Kolodkin AL. Neuropilin-2/PlexinA3 Receptors Associate with GluA1 and Mediate Sema3F-Dependent Homeostatic Scaling in Cortical Neurons. Neuron. 2017 Nov 14. pii: S0896-6273(17)31021-8. doi: 10.1016/j.neuron.2017.10.029. [Epub ahead of print]
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Tue 17th October 2017
Publications - October 2017
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Sat 30th September 2017
Publications - September 2017
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Thu 31st August 2017
Blackshaw group reports in Nature the discovery of sleep-promoting neurons in the mammalian hypothalamus
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Mon 31st July 2017
Publications - July 2017
Publications from Primary Faculty Members - July 2017:
Fraser KM, Janak PH. Long-lasting contribution of dopamine in the nucleus accumbens core, but not dorsal lateral striatum, to sign-tracking. Eur J Neurosci. 2017 Jul 12. doi: 10.1111/ejn.13642. [Epub ahead of print]
Langseth AJ, Kim J, Ugolino JE, Shah Y, Hwang HY, Wang J, Bergles DE, Brown SP. Cell-type specific differences in promoter activity of the ALS-linked C9orf72 mouse ortholog. Sci Rep. 2017 Jul 18;7(1):5685. doi: 10.1038/s41598-017-05864-2.
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Thu 22nd June 2017
Publications - June 2017
Publications from Primary Faculty Members - June 2017:
Harraz MM, Snyder SH. Antidepressant Actions of Ketamine Mediated by the Mechanistic Target of Rapamycin, Nitric Oxide, and Rheb. Neurotherapeutics. 2017 Jun 13. doi: 10.1007/s13311-017-0540-0. [Epub ahead of print]
Jeck DM, Qin M, Egeth H, Niebur E. Attentive pointing in natural scenes correlates with other measures of attention. Vision Res. 2017 Jun;135:54-64. doi: 10.1016/j.visres.2017.04.001. Epub 2017 May 8.
Vasavda C, Zaccor NW, Scherer PC, Sumner CJ, Snyder SH. Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding. J Vis Exp. 2017 Jun 9;(124). doi: 10.3791/55561.
Wang Q, Yue WWS, Jiang Z, Xue T, Kang SH, Bergles DE, Mikoshiba K, Offermanns S, Yau KW. Synergistic Signaling by Light and Acetylcholine in Mouse Iris Sphincter Muscle. Curr Biol. 2017 Jun 19;27(12):1791-1800.e5. doi: 10.1016/j.cub.2017.05.022. Epub 2017 Jun 1.
Xie X, Tabuchi M, Brown MP, Mitchell SP, Wu MN, Kolodkin AL. The laminar organization of the Drosophila ellipsoid body is semaphorin-dependent and prevents the formation of ectopic synaptic connections. Elife. 2017 Jun 20;6. pii: e25328. doi: 10.7554/eLife.25328. [Epub ahead of print]
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Tue 20th June 2017
Work by the Yau lab confirms melanopsin light-sensitive muscles influence pupil constriction in many mammalian eyes
In a report in the June 19 issue of the journal Current Biology, Neuroscience Professor King-Wai Yau and colleagues detail how the pupils in a mouse’s eyes get smaller when the animal is moved from a dark to a lit room even when the nerve connections between the animal’s brain and eyes are severed.
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Wed 31st May 2017
Publications - May 2017
Publications from Primary Faculty Members - May 2017:
Cox E, Hwang W, Uzoma I, Hu J, Guzzo CM, Jeong J, Matunis MJ, Qian J, Zhu H, Blackshaw S. Global Analysis of SUMO-Binding Proteins Identifies SUMOylation as a Key Regulator of the INO80 Chromatin Remodeling Complex. Mol Cell Proteomics. 2017 May;16(5):812-823. doi: 10.1074/mcp.M116.063719. Epub 2017 Mar 2.
Kajstura TJ, Dougherty SE, Linden DJ. Serotonin axons in the neocortex of the adult female mouse regrow after traumatic brain injury. J Neurosci Res. 2017 May 9. doi: 10.1002/jnr.24059. [Epub ahead of print]
Severson KS, Xu D, Van de Loo M, Bai L, Ginty DD, O'Connor DH. Active Touch and Self-Motion Encoding by Merkel Cell-Associated Afferents. Neuron. 2017 May 3;94(3):666-676.e9. doi: 10.1016/j.neuron.2017.03.045. Epub 2017 Apr 20.
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Fri 21st April 2017
Neuroscience Graduate Student's Research on Huntington's Disease Featured in Neuron
Jonathan Grima, a Neuroscience Graduate Student in Dr. Jeffrey Rothstein's lab, recently reported his research in Neuron regarding a potential cellular cause for neurodegenerative diseases like Huntington's Disease. Jonathan, and his work, were also featured in a recent Baltimore Sun article.
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Sat 1st April 2017
Publications- April 2017
Publications from Primary Faculty Members - April 2017:
Grima JC, Daigle JG, Arbez N, Cunningham KC, Zhang K, Ochaba J, Geater C, Morozko E, Stocksdale J, Glatzer JC, Pham JT, Ahmed I, Peng Q, Wadhwa H, Pletnikova O, Troncoso JC, Duan W, Snyder SH, Ranum LP, Thompson LM, Lloyd TE, Ross CA, Rothstein JD. Mutant Huntingtin Disrupts the Nuclear Pore Complex. Neuron.2017 Apr 5;94(1):93-107.e6. doi: 10.1016/j.neuron.2017.03.023.
Pouget P, Murthy A, Stuphorn V. Cortical control and performance monitoring of interrupting and redirecting movements. Philos Trans R Soc Lond B Biol Sci. 2017 Apr 19;372(1718). pii: 20160201. doi: 10.1098/rstb.2016.0201.
Roth RH, Zhang, Y, Huganir RL. Dynamic imaging of AMPA receptor trafficking in vitro and in vivo. Curr Opin Neurobiol. 2017 Apr 12;45:51-58. doi: 10.1016/j.conb.2017.03.008. [Epub ahead of print]
Weeks HM, Therrien AS, Bastian AJ. Proprioceptive Localization Deficits in People With Cerebellar Damage. Cerebellum. 2017 Apr;16(2):427-437. doi: 10.1007/s12311-016-0819-4.
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Thu 2nd March 2017
Bergles Lab work featured on cover of Neuron
In a recent issue of Neuron, Agarwal et al. (2017) report that calcium efflux from mitochondria during brief openings of the mitochondrial permeability transition pore (mPTP) contribute to calcium microdomains.
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Wed 1st March 2017
Publications - March 2017
Publications from Primary Faculty Members - March 2017:
Chiu SL, Diering GH, Ye B, Takamiya K, Chen CM, Jiang Y, Niranjan T, Schwartz CE, Wang T, Huganir RL. GRASP1 Regulates Synaptic Plasticity and Learning through Endosomal Recycling of AMPA Receptors. Neuron. 2017 Mar 8. pii: S0896-6273(17)30139-3. doi: 10.1016/j.neuron.2017.02.031. [Epub ahead of print]
Cox E, Hwang W, Uzoma I, Hu J, Guzzo C, Jeong J, Matunis M, Qian J, Zhu H, Blackshaw S. Global analysis of SUMO-binding proteins identifies SUMOylation as a key regulator of the INO80 chromatin remodeling complex. Mol Cell Proteomics. 2017 Mar 2. pii: mcp.M116.063719. doi: 10.1074/mcp.M116.063719. [Epub ahead of print]
Gao M, Whitt JL, Huang S, Lee A, Mihalas S, Kirkwood A, Lee HK. Experience-dependent homeostasis of 'noise' at inhibitory synapses preserves information coding in adult visual cortex. Philos Trans R Soc Lond B Biol Sci. 2017 Mar 5;372(1715). pii: 20160156. doi: 10.1098/rstb.2016.0156.
Li Z, Tseng PY, Tiwari V, Xu Q, He SQ, Wang Y, Zheng Q, Han L, Wu Z, Blobaum AL, Cui Y, Tiwari V, Sun S, Cheng Y, Huang-Lionnet JH, Geng Y, Xiao B, Peng J, Hopkins C, Raja SN, Guan Y, Dong X. Targeting human Mas-related G protein-coupled receptor X1 to inhibit persistent pain. Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):E1996-E2005. doi: 10.1073/pnas.1615255114. Epub 2017 Feb 21.
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Thu 23rd February 2017
Xinzhong Dong's lab reports in the current issue of Neuron how itch-detecting neurons manage pain
It is a puzzle that troubles the field for many years that how pain and itch, two closely related sensations (once thought as one sensation), are differentiated by the nervous systems. Coding of pain and itch are heatedly debated for decades. The current specificity theory suggests that these two kinds of signals are carried by separate pathways, with some interactions, for example pain can inhibit itch and that explains why we all scratch to inhibit pain. It is true in the periphery (our previous study indicate a small population of neurons in the periphery only codes for itch sensation), but a study from our lab suggests that there could be more crosstalk between these two sensations in the central than we expected. People might not notice in real life, but in human psychophysical studies, well-isolated experimental environments, when human subjects are given itchy substances, they typically report intense itch sensations accompanied by minor noxious sensations, such as pricking, stinging and burning. Our new leaky gate model suggest in certain circumstances intense itch signals can trigger minor pain sensations, which can explain such phenomenon.
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Wed 22nd February 2017
Xinzhong Dong's Lab reports in the current issue of PNAS about the role of MRGPRX1 in persistent pain
Chronic pain is a major health and economic problem worldwide with an estimated prevalence reaching epidemic levels of >25% of the population. For example in the US, chronic pain affects over 116 million adults and costs up to $635 billion annually in treatment and lost productivity. Most drugs on the market for chronic pain have undesired side effects because their targets exist both inside and outside the pain pathways. MrgprX1, a human GPCR, is a promising target of novel pain inhibitors, mainly because of its restricted expression in pain-sensing neurons. Many pharmaceutical companies have conducted drug screens to target human MrgprX1. However, constrained by species differences across Mrgprs, many drug candidates activate MrgprX1 but not the rodent orthologues, leaving no animal model responsive to test the effect on pain in vivo. To overcome the species specificity problem, Xinzhong Dong's lab generated a transgenic mouse line in which they replaced mouse Mrgprs with human MrgprX1. This valuable humanized mouse allowed them to characterize a potent positive allosteric modulator of MrgprX1, ML382. Cellular studies in humanized MrgprX1 mice suggest that ML382 enhances the ability of MrgprX1 to inhibit N-type Ca2+ channels via the Gi pathway in nociceptive neurons and block presynaptic terminal transmission in spinal cord. Importantly, ML382 effectively attenuates evoked persistent and spontaneous pain without causing peripheral or central side effects such as itch, motor dysfunction, or reward in the naïve condition. The group's findings suggest that humanized MrgprX1 mice provide an essential preclinical model and that activating MRGPRX1 is an effective way to treat persistent pain.
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Thu 16th February 2017
New Research Investigating Cellular Basis of Memory from Knierim Lab Appears in Neuron
The hippocampus is a brain area involved in learning and memory. The dentate gyrus, a subregion of the hippocampus, may prevent interference between similar memories, but it is unclear how the two main dentate gyrus cell types, granule cells and mossy cells, contribute to this process. GoodSmith et al. recorded from granule cells and mossy cells as rats explored distinct environments. Different groups of granule cells fired in different environments, but mossy cells fired in multiple locations in most environments, a feature previously attributed to granule cells. This study resolves a longstanding debate about the firing properties of granule cells, shows that mossy cells have spatial firing, and describes distinct ways in which granule cells and mossy cells can contribute to the ability to distinguish between environments.
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Tue 7th February 2017
New study by Huganir Lab in Science reveals synapse dynamics during sleep
Sleep is an essential process that plays a critical role in supporting cognitive functions such as learning and memory consolidation. Synapses in the brain are the structures responsible for forming and maintaining memories. Studying mice, we found that synapses become stronger while the mice were awake and weaker during sleep by removal of the neurotransmitter receptors called AMPA receptors. This is a process called homeostatic scaling-down. Scaling-down during sleep was driven by a protein called Homer1a which builds up in neurons while the mice were awake but is prevented from accessing the synapses until sleep, by the arousal promoting neuromodulator noradrenaline. In this way, the scaling of synapses is limited while awake and engaged as we transition to sleep. Homer1a targeting to synapses was also observed during sleep deprivation, activated by the sleep promoting neuromodulator adenosine. Sleep is well known to enhance memory consolidation whereas sleep deprivation greatly impairs memory formation. Our study suggests that weakening of synapses during sleep contributes to learning and memory, and that if this process is engaged during sleep deprivation memories become lost.
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Wed 1st February 2017
Publications - February 2017
Publications from Primary Faculty Members - February 2017:
Agarwal A, Wu PH, Hughes EG, Fukaya M, Tischfield MA, Langseth AJ, Wirtz D, Bergles DE. Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes. Neuron. 2017 Feb 8;93(3):587-605.e7. doi: 10.1016/j.neuron.2016.12.034. Epub 2017 Jan 26.
Diering GH, Nirujogi RS, Roth RH, Worley PF, Pandey A, Huganir RL. Homer1a drives homeostatic scaling-down of excitatory synapses during sleep. Science. 2017 Feb 3;355(6324):511-515. doi: 10.1126/science.aai8355. Epub 2017 Feb 2.
Fu C, Xu J, Cheng W, Rojas T, Chin AC, Snowman AM, Harraz MM, Snyder SH. Neuronal migration is mediated by inositol hexakisphosphate kinase 1 via α-actinin and focal adhesion kinase. Proc Natl Acad Sci U S A. 2017 Feb 2. pii: 201700165. doi: 10.1073/pnas.1700165114. [Epub ahead of print]
GoodSmith D, Chen X, Wang C, Kim SH, Song H, Burgalossi A, Christian KM, Knierim JJ. Spatial Representations of Granule Cells and Mossy Cells of the Dentate Gyrus. Neuron. 2017 Feb 8;93(3):677-690.e5. doi: 10.1016/j.neuron.2016.12.026. Epub 2017 Jan 26.
Smith-Hicks CL, Cai P, Savonenko AV, Reeves RH, Worley PF. Increased Sparsity of Hippocampal CA1 Neuronal Ensembles in a Mouse Model of Down Syndrome. Front Neural Circuits. 2017 Feb 3;11:6. doi: 10.3389/fncir.2017.00006. eCollection 2017.
Sun S, Xu Q, Guo C, Guan Y, Liu Q, Dong X. Leaky Gate Model: Intensity-Dependent Coding of Pain and Itch in the Spinal Cord. Neuron. 2017 Feb 22;93(4):840-853.e5. doi: 10.1016/j.neuron.2017.01.012.
Yue WW, Frederiksen R, Ren X, Luo DG, Yamashita T, Shichida Y, Cornwall MC, Yau KW. Spontaneous activation of visual pigments in relation to openness/closedness of chromophore-binding pocket. Elife. 2017 Feb 10;6. pii: e18492. doi: 10.7554/eLife.18492.
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Wed 4th January 2017
Blackshaw Lab identifies link between master clock and control of sleep and body temperature.
A clump of just a few thousand brain cells, no bigger than a mustard seed, controls the daily ebb and flow of most bodily processes in mammals -- sleep/wake cycles, most notably. Now, Johns Hopkins scientists report direct evidence in mice for how those cell clusters control sleep and relay light cues about night and day throughout the body.
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Sun 1st January 2017
Publications - January 2017
Publications from Primary Faculty Members - January 2017:
Cave C, Park S, Rodriguez M, Nakamura M, Hoke A, Pletnikov M, Sockanathan S. GDE2 is essential for neuronal survival in the postnatal mammalian spinal cord. Mol Neurodegener. 2017 Jan 19;12(1):8. doi: 10.1186/s13024-017-0148-1.
Lagerlöf O, Hart GW, Huganir RL. O-GlcNAc transferase regulates excitatory synapse maturity. Proc Natl Acad Sci U S A. 2017 Jan 31. pii: 201621367. doi: 10.1073/pnas.1621367114. [Epub ahead of print]
Savelli F, Luck JD, Knierim JJ. Framing of grid cells within and beyond navigation boundaries. Elife. 2017 Jan 13;6. pii: e21354. doi: 10.7554/eLife.21354. [Epub ahead of print]
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Thu 1st December 2016
Publications - December 2016
Publications from Primary Faculty Members - December 2016:
Bedont JL, LeGates TA, Buhr E, Bathini A, Ling JP, Bell B, Wu MN, Wong PC, Van Gelder RN, Mongrain V, Hattar S, Blackshaw S. An LHX1-Regulated Transcriptional Network Controls Sleep/Wake Coupling and Thermal Resistance of the Central Circadian Clockworks. Curr Biol. 2017 Jan 9;27(1):128-136. doi: 10.1016/j.cub.2016.11.008. Epub 2016 Dec 22.
Cave, C, Sockanathan, S. Transcription Factor Hand-offs "Enhance" Motor Neuron Differentiation. Neuron. 2016 Dec 21;92(6):1149-1151. doi: 10.1016/j.neuron.2016.12.009.
Williford JR, von der Heydt R. Figure-Ground Organization in Visual Cortex for Natural Scenes. eNeuro. 2016 Dec 29;3(6). pii: ENEURO.0127-16.2016. doi: 10.1523/ENEURO.0127-16.2016.
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Tue 1st November 2016
Publications - November 2016
Publications from Primary Faculty Members - November 2016:
Thein, T, de Melo, J, Zibetti, C, Clark, BS, Juarez, F, Blackshaw, S. Control of lens development by Lhx2-regulated neuroretinal FGFs. Development. 2016 Nov 1;143(21):3994-4002.
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Sat 1st October 2016
Publications - October 2016
Publications from Primary Faculty Members - October 2016:
Finley, JM, Bastian, AJ. Associations Between Foot Placement Asymmetries and Metabolic Cost of Transport in Hemiparetic Gait. Neuroehabil Neural Repair. 2016 Oct 20. pii: 1545968316675428. [Epub ahead of print]
Corbit, LH, Janak, PH. Changes in the Influence of Alcohol-Paired Stimuli on Alcohol Seeking across Extended Training. Front Psychiatry. 2016 Oct 10;7:169. eCollection 2016.
Gu, Y, Huganir, ...
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Thu 1st September 2016
Publications - September 2016
Publications from Primary Faculty Members - September 2016
Gillary G, Niebur E. The Edge of Stability: Response Times and Delta Oscillations in Balanced Networks. PLoS Comput Biol. 2016 Sep 30;12(9):e1005121. doi: 10.1371/journal.pcbi.1005121. eCollection 2016.
Roemmich RT, Long AW, Bastian AJ. Seeing the Errors You Feel Enhances Locomotor Performance but Not Learning.Curr Biol. 2016 Sep 15. pii: S0960-9822(16)30924-1. doi: 10.1016/j.cub.2016.08.012. [Epub ahead of prin...
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Mon 29th August 2016
Foster lab reports in Neuron how rats form memories associated with food rewards.
The Brain Uses Backward Instant Replays to Remember Important Travel Routes
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Mon 1st August 2016
Publications - August 2016
Publications from Primary Faculty Members - August 2016
Diering GH, Heo S, Hussain NK, Liu B, Huganir RL. Extensive phosphorylation of AMPA receptors in neurons. Proc Natl Acad Sci U S A. 2016 Aug 16;113(33):E4920-7. doi: 10.1073/pnas.1610631113. Epub 2016 Aug 1.
Jin Y, Dougherty SE, Wood K, Sun L, Cudmore RH, Abdalla A, Kannan G, Pletnikov M, Hashemi P, Linden DJ. Regrowth of Serotonin Axons in the Adult Mouse Brain Following Injury. Neuron. 2016 Aug 17;91(4):748-62. doi:...
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Fri 1st July 2016
Publications - July 2016
Publications from Primary Faculty Members - July 2016
Na Y, Park S, Lee C, Kim DK, Park JM, Sockanathan S, Huganir RL, Worley PF. Real-Time Imaging Reveals Properties of Glutamate-Induced Arc/Arg 3.1 Translation in Neuronal Dendrites. Neuron. 2016 Jul 5. pii: S0896-6273(16)30294-X. doi: 10.1016/j.neuron.2016.06.017. [Epub ahead of print]
Wagatsuma N, von der Heydt R, Niebur E. Spike Synchrony Generated by Modulatory Common Input through NMDA-type Synapses. J Neurophysiol. 2016 J...
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Thu 2nd June 2016
Wu lab identifies neural circuits underlying sleep drive in flies
'You Are Getting Sleepy,' Said The Scientist To The Fruit Fly
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Wed 1st June 2016
Publications - June 2016
Publications from Primary Faculty Members - June 2016
Hart, RP, Goff, LA. Long Noncoding RNAs: Central to Nervous System Development. Int J Dev Neurosci. 2016 Jun 10. pii: S0736-5748(16)30109-5. doi: 10.1016/j.ijdevneu.2016.06.001. [Epub ahead of print]
Gomez-Ramirez M, Hysaj K, Niebur E. Neural mechanisms of selective attention in the somatosensory system. J Neurophysiol. 2016 Jun 22:jn.00637.2015. doi: 10.1152/jn.00637.2015. [Epub ahead of print]
Lin CC, Potter CJ. Editi...
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Tue 24th May 2016
Publications - April 2016
Publications from Primary Faculty Members - April 2016
Evsen L, Doetzlhofer A. Gene Transfer into the Chicken Auditory Organ by In Ovo Micro-electroporation. J Vis Exp. 2016 Apr 17;(110). doi: 10.3791/53864.
Fu X, Shah A, Baraban JM. Rapid reversal of translational silencing: Emerging role of microRNA degradation pathways in neuronal plasticity. Neurobiol Learn Mem. 2016 Apr 20. pii: S1074-7427(16)30028-4. doi: 10.1016/j.nlm.2016.04.006. [Epub ahead of print]
Musselman KE,...
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Thu 31st March 2016
Publications - March 2016
Publications from Primary Faculty Members - March 2016
Corbit LH, Fischbach SC, Janak PH. Nucleus Accumbens Core and Shell are Differentially Involved in General and Outcome-Specific Forms of Pavlovian-Instrumental Transfer with Alcohol and Sucrose Rewards. Eur J Neurosci. 2016 Mar 11. doi: 10.1111/ejn.13235. [Epub ahead of print]
Harraz MM, Tyagi R, Cortés P, Snyder SH. Antidepressant action of ketamine via mTOR is mediated by inhibition of nitrergic Rheb degradat...
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Mon 29th February 2016
Publications - February 2016
Publications from Primary Faculty Members - February 2016
de Melo J, Zibetti C, Clark BS, Hwang W, Miranda-Angulo AL, Qian J, Blackshaw S. Lhx2 Is an Essential Factor for Retinal Gliogenesis and Notch Signaling. J Neurosci. 2016 Feb 24;36(8):2391-405. doi: 10.1523/JNEUROSCI.3145-15.2016.
Gu Y, Chiu SL, Liu B, Wu PH, Delannoy M, Lin DT, Wirtz D, Huganir RL. Differential vesicular sorting of AMPA and GABAA receptors.Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E922-31. doi: 10.107...
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Sun 31st January 2016
Publications - January 2016
Publications from Primary Faculty Members - January 2016
Campbell DP, Chrysostomou E, Doetzlhofer A. Canonical Notch signaling plays an instructive role in auditory supporting cell development. Sci Rep. 2016 Jan 20;6:19484. doi: 10.1038/srep19484.
Kim J, Matney CJ, Roth RH, Brown SP. Synaptic Organization of the Neuronal Circuits of the Claustrum. J Neurosci. 2016 Jan 20;36(3):773-84. doi: 10.1523/JNEUROSCI.3643-15.2016.
Therrien AS, Wolpert DM, Bastian AJ. Effective ...
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Thu 31st December 2015
Publications - December 2015
Publications from Primary Faculty Members - December 2015
Huang S, Hokenson K, Bandyopadhyay S, Russek SJ, Kirkwood A. Brief Dark Exposure Reduces Tonic Inhibition in Visual Cortex. J Neurosci. 2015 Dec 2;35(48):15916-20. doi: 10.1523/JNEUROSCI.1813-15.2015.
Silva, D, Feng, T, Foster, DJ. Trajectory events across hippocampal place cells require previous experience. Nat Neurosci. 2015 Dec;18(12):1772-9. doi: 10.1038/nn.4151. Epub 2015 Oct 26.
Vazquez A, Statton MA, Busgang ...
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Mon 30th November 2015
Publications - November 2015
Publications from Primary Faculty Members - November 2015
Chen X, Stuphorn V. Sequential selection of economic good and action in medial frontal cortex of macaques during value-based decisions. Elife. 2015 Nov 27;4. pii: e09418. doi: 10.7554/eLife.09418.
He K, Huertas M, Hong SZ, Tie 1, Hell JW, Shouval H, Kirkwood A. Distinct Eligibility Traces for LTP and LTD in Cortical Synapses. Neuron. 2015 Nov 4;88(3):528-38. doi: 10.1016/j.neuron.2015.09.037. Epub 2015 Oct 22.
Rober...
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Sat 31st October 2015
Publications - October 2015
Publications from Primary Faculty Members - October 2015
Hussain NK, Thomas GM, Luo J, Huganir RL. Regulation of AMPA receptor subunit GluA1 surface expression by PAK3 phosphorylation. Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):E5883-90. doi: 10.1073/pnas.1518382112. Epub 2015 Oct 12.
Lin CC, Potter CJ. Re-Classification of Drosophila melanogaster Trichoid and Intermediate Sensilla Using Fluorescence-Guided Single Sensillum Recording. PLoS One. 2015 Oct 2;10(10):e0139675...
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Wed 30th September 2015
Publications - September 2015
Publications from Primary Faculty Members - September 2015
Bedont JL, Newman EA, Blackshaw S. Patterning, specification, and differentiation in the developing hypothalamus. Wiley Interdiscip Rev Dev Biol. 2015 Sep;4(5):445-68. doi: 10.1002/wdev.187. Epub 2015 Mar 27.
Larson, VA, Zhang, Y, Bergles, DE. Electrophysiological properties of NG2+ cells: Matching physiological studies with gene expression profiles. Brain Res. 2015 Sep 15. pii: S0006-8993(15)00708-8. doi: 10.1016/j...
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Mon 31st August 2015
Publications - August 2015
Publications from Primary Faculty Members - August 2015
Ahmed I, Sbodio JI, Harraz MM, Tyagi R, Grima JC, Albacarys LK, Hubbi ME, Xu R, Kim S, Paul BD, Snyder SH. Huntington's disease: Neural dysfunction linked to inositol polyphosphate multikinase. Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):9751-6. doi: 10.1073/pnas.1511810112. Epub 2015 Jul 20.
Fu C, Xu J, Li RJ, Crawford JA, Khan AB, Ma TM, Cha JY, Snowman AM, Pletnikov MV, Snyder SH. Inositol Hexakisphosphate Kinase-3 Regu...
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Thu 30th July 2015
Publications - July 2015
Publications from Primary Faculty Members - July 2015
Golden EJ, Benito-Gonzalez A, Doetzlhofer A. The RNA-binding protein LIN28B regulates developmental timing in the mammalian cochlea. Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):E3864-73. doi: 10.1073/pnas.1501077112. Epub 2015 Jul 2.
Hand, RA. Khalid, S, Tam, E, Kolodkin, AL. Axon Dynamics during Neocortical Laminar Innervation. Cell Rep. 2015 Jul 14;12(2):172-82. doi: 10.1016/j.celrep.2015.06.026. Epub 2015 Ju...
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Wed 17th June 2015
Publications - June 2015
Publications from Primary Faculty Members - June 2015
Petrus E, Rodriguez G, Patterson R, Connor B, Kanold PO, Lee HK. Vision Loss Shifts the Balance of Feedforward and Intracortical Circuits in Opposite Directions in Mouse Primary Auditory and Visual Cortices.
J Neurosci. 2015 Jun 10;35(3)8790-801. doi: 10.1523/JNEUROSCI.4975-14.2015.
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